Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Retirement, physical activity linked to longer sleep in old adults

15 Jan 2020
Elderly thinking becoming frail and slow is 'normal'

Majority of elderly adults meet the recommended total sleep time (TST), a new Ireland study has found. Suboptimal sleep in this population appear to be related to modifiable factors, such as medication, employment and physical activity.

Researchers conducted a cross-sectional analysis on 1,533 elderly adults (mean age, 67.5±9.1 years) who were given a wrist-worn accelerometer for the measurement of sleep parameters. Among the data collected were TST and self-reported sleep problems. The US National Sleep Foundation guidelines were used as basis for determining whether participants met sleep recommendations.

The mean TST was 463±73 minutes, with entries ranging from 164 to 779 minutes. Majority (80.2 percent) of those aged 50–64 years met the recommended sleeping range of 7–9 hours; 15.0 percent slept less, and 4.8 percent slept longer.

In the 65-year age group, 61.1 percent met the recommended sleeping duration of 7–8 hours, with 13.0 percent and 25.9 percent having shorter and longer TSTs, respectively.

Multinomial logistic regression analysis found that having self-reported sleep problems significantly decreased TST (B, –3.58, 95 percent confidence interval [CI], –6.00 to –1.17; p<0.01) while increasing the risk of short sleep (relative risk ratio [RRR], 1.12, 95 percent CI, 1.01–1.23 p<0.05).

On the other hand, those who were retired (RRR, 3.36, 95 percent CI, 1.91–5.90; p<0.001) or unemployed (RRR, 2.64, 95 percent CI, 1.42–4.92; p<0.01) were more likely than their employed counterparts to have longer sleep. The same was true for age (RRR, 1.05, 95 percent CI, 1.03–1.08; p<0.001) and use of antidepressant medication (RRR, 1.66, 95 percent CI, 1.03–2.70; p<0.05).

Physical activity likewise had an important role to play. Moderate physical activity cut the risk of short sleep (RRR, 0.67, 95 percent CI, 0.45–0.99; p<0.05) relative to low levels. High physical activity was inversely correlated with the likelihood of long sleep (RRR, 0.60, 95 percent CI, 0.39–0.93; p<0.05).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.