Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 18 hours ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 6 days ago
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.

Retinol‐binding protein a promising biomarker for recalcitrant warts

18 Jun 2019

Low serum retinol-binding protein (RBP) represents a relatively cheap and reliable biomarker for recalcitrant cutaneous warts, a study suggests.

Researchers evaluated serum RBP level via enzyme-linked immunosorbent assay in 50 patients with recalcitrant cutaneous warts (mean age, 28.3 years; 42 percent male; mean disease duration, 16.5 months) and 30 apparently healthy controls (mean age, 27.1 years; 36.7 percent male). Among patients with warts, 38 (76 percent) had a progressive course of the disease. The size of warts was <1 cm in 17 patients (34 percent) and 1 cm in 33 (66 percent).

A total of 30 patients (60 percent) had multiple warts, and the most frequent types observed were plantar (48 percent) and common (46 percent) warts.

Compared with controls, warts patients had significantly lower serum RBP levels (p<0.001). However, serum RBP concentration did not differ by clinical parameters in the group of patients with warts (p>0.05 for all).

Receiver operating curve analysis showed that serum RBP at a cutoff value ≤1,034.6 lg/ml differentiated patients with recalcitrant warts from healthy controls with 100 percent sensitivity and specificity (p<0.001).

The findings suggest that low serum RBP levels may serve as a reliable indicator of vitamin A (retinol) deficiency, which could explain the persistence of the cutaneous warts in the studied patients, according to the researchers.

Given that cutaneous viral warts are benign epidermal proliferations caused by human papillomaviruses (HPVs), the current data hold promise for opening a new avenue for preventive and/or therapeutic strategies in the field of HPV infection, they added.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 18 hours ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 6 days ago
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.