Most Read Articles
Stephen Padilla, 5 days ago
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Retinol‐binding protein a promising biomarker for recalcitrant warts

18 Jun 2019

Low serum retinol-binding protein (RBP) represents a relatively cheap and reliable biomarker for recalcitrant cutaneous warts, a study suggests.

Researchers evaluated serum RBP level via enzyme-linked immunosorbent assay in 50 patients with recalcitrant cutaneous warts (mean age, 28.3 years; 42 percent male; mean disease duration, 16.5 months) and 30 apparently healthy controls (mean age, 27.1 years; 36.7 percent male). Among patients with warts, 38 (76 percent) had a progressive course of the disease. The size of warts was <1 cm in 17 patients (34 percent) and 1 cm in 33 (66 percent).

A total of 30 patients (60 percent) had multiple warts, and the most frequent types observed were plantar (48 percent) and common (46 percent) warts.

Compared with controls, warts patients had significantly lower serum RBP levels (p<0.001). However, serum RBP concentration did not differ by clinical parameters in the group of patients with warts (p>0.05 for all).

Receiver operating curve analysis showed that serum RBP at a cutoff value ≤1,034.6 lg/ml differentiated patients with recalcitrant warts from healthy controls with 100 percent sensitivity and specificity (p<0.001).

The findings suggest that low serum RBP levels may serve as a reliable indicator of vitamin A (retinol) deficiency, which could explain the persistence of the cutaneous warts in the studied patients, according to the researchers.

Given that cutaneous viral warts are benign epidermal proliferations caused by human papillomaviruses (HPVs), the current data hold promise for opening a new avenue for preventive and/or therapeutic strategies in the field of HPV infection, they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 5 days ago
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.