Most Read Articles
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Roshini Claire Anthony, 24 Apr 2020

The gap in overall life expectancy between people with HIV (PWH) and those without HIV has narrowed over time, particularly among optimally treated PWH. However, PWH still have fewer comorbidity-free years than those without HIV, according to a study presented at CROI 2020.

Restless legs syndrome common in IPF, tied to poor sleep quality

02 May 2020

Restless legs syndrome (RLS) is prevalent in patients with idiopathic pulmonary fibrosis (IPF) and negatively affects sleep quality, a recent study has found.

The study involved 50 IPF patients (mean age, 72 years; 76 percent male) and 293 controls referred for suspected sleep disorders (mean age, 69.1 years; 75.3 percent male). RLS was diagnosed using the validated 5-item RLS criteria, while sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI; a score of ≥5 indicated poor sleep quality).

In the IPF group, 36 patients (76 percent) were receiving pirfenidone and 14 (24 percent) nintedanib, 22 (44 percent) were on long-term oxygen, and 32 (64 percent) were former smokers. The average PSQI score was 7.80, with 38 patients (76 percent) having scores ≥5.

RLS prevalence was significantly higher in the IPF group than in the control group (24.0 percent vs 10.9 percent; p=0.011). Among IPF patients, those with vs without RLS had markedly higher mean PSQI score (10.6 vs 6.9; p=0.005).

Logistic regression analysis controlling for demographics and clinical parameters of disease severity confirmed the association between higher PSQI score and RLS (odds ratio, 1.38, 95 percent confidence interval, 1.08–1.76; p=0.01).

According to the researchers, RLS can be treated using low doses of dopaminergic drugs (eg, pramipexole in the slow-release formulation). Treatment yields a prompt amelioration of both subjective symptoms (sensory discomfort and restlessness) and motor-associated phenomena (periodic limb movements during wake and sleep). Treatment should therefore be considered in all patients with severe RLS and related sleep difficulties or disruption.

However, the researchers emphasized the need for prospective research to assess the benefit–risk ratio of specific therapeutic interventions for RLS in IPF.

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Most Read Articles
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Roshini Claire Anthony, 24 Apr 2020

The gap in overall life expectancy between people with HIV (PWH) and those without HIV has narrowed over time, particularly among optimally treated PWH. However, PWH still have fewer comorbidity-free years than those without HIV, according to a study presented at CROI 2020.