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6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
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New drug applications approved by US FDA as of 1 - 15 June 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Pearl Toh, 6 days ago
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Response to antipsychotic drug in acute schizophrenia remains stable over the years

09 Oct 2017
The second generation injection may cost up to HK$5000 per month.

A meta-analysis of all placebo-controlled trials in patients with acute exacerbations of schizophrenia over a 60-year period has found about twice as many patients improving with antipsychotics as with placebo. However, only a subgroup of patients has had a positive response.

Furthermore, “[e]ffect sizes were reduced by industry and increasing placebo response, not decreasing drug response,” according to researchers, adding that drug development may benefit from smaller samples but better-selected patients.

Multiple electronic databases were searched. The primary outcome was overall efficacy, and secondary outcomes included responder and dropout rates; positive, negative and depressive symptoms; quality of life; functioning; and major side effects. Meta-regression was used to analyse potential moderators of efficacy.

A total of 167 double-blind randomized controlled trials met the inclusion criteria, with 28,102 mainly chronic participants. The standardized mean difference (SMD) for overall efficacy was 0.47 (95 percent CI, 0.42 to 0.51). SMD was reduced to 0.38 after accounting for small-trial effects and publication bias.

Significantly more patients in the antipsychotic group, compared with those in the placebo group, had at least a “minimal” (51 vs 30 percent) and a “good” (23 vs 14 percent) response.

Positive symptoms (SMD, 0.45) improved more than negative symptoms (SMD, 0.35) and depression (SMD, 0.27). There was improvement as well in quality of life (SMD, 0.35) and functioning (SMD, 0.34) even in the short term. Antipsychotics had substantially varied side effects.

A total of 16 trial characteristics of the response predictors analysed had changed over the decades. A multivariable meta-regression revealed, however, that only industry sponsorship and increasing placebo response were significant moderators of effect sizes. Drug response remained stable over time, according to researchers.

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Most Read Articles
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
6 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.
15 Jun 2018
New drug applications approved by US FDA as of 1 - 15 June 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Pearl Toh, 6 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.