Most Read Articles
24 Jun 2015
Persistent sleepless nights can take their toll on sufferers, and leave some insomniacs gasping for a caffeine hit just to get them through the morning slog.
01 Aug 2012

Proper use of family planning methods is the key to preventing unplanned preg­nancies. Despite the great effort spent in the research and development of contra­ceptive methods resulting in many new advances, none of the current methods is 100% effective. Emergency contraception (EC), also called ‘postcoital contraception’, is a back-up contraception adminis­tered to a woman after unprotected sexual intercourse (UPSI) or contraceptive failure, so as to prevent unplanned pregnancy. This may be indicated when unexpected intercourse has occurred without the use of any contraception, when there is a sus­pected potential failure of one’s regular contraceptive method (eg, condom break­age or slippage, missed dose of hormonal contraceptive, or potential failure of an intrauterine contraceptive device), or after sexual assault.

Roshini Claire Anthony, 27 Dec 2017

A once-daily subcutaneous dose of teriparatide may be more effective than once-weekly oral risedronate in preventing vertebral fractures in post-menopausal women with osteoporosis and a history of vertebral fractures, findings from the VERO* trial show.

Yesterday
Several adults who experienced a first-time myocardial infarction (MI) at a young age have been found to be ineligible for statin therapy based on current guideline-based treatment thresholds, reports a study, stressing the need for better risk assessment tools among young adults.

Rescue therapy with mycophenolate mofetil moderately effective in AIH

11 Nov 2017

Use of mycophenolate mofetil (MMF) as rescue therapy in patients with autoimmune hepatitis (AIH) appears to be well tolerated, with moderate efficacy for inducing remission, according to data from the Tapestry study. However, response rates may be lower and infection rates higher in the presence of cirrhosis.

Researchers reviewed the medical records of 105 AIH patients who received MMF after an inadequate response or intolerance to standard therapy. Data of interest were baseline demographics, liver disease characteristics, initial therapy, MMF indications, treatment outcome and side effects.

Of the patients, 98 percent were previously treated with the combination of corticosteroids and thiopurine. Indications for MMF included treatment nonresponse (40 percent) and intolerance to therapy (60 percent).

After a median treatment duration of 12 weeks, 63 (60 percent) patients achieved biochemical remission with MMF. Treatment response in the group receiving MMF due to nonresponse to previous treatment was comparable to that in the group receiving MMF due to intolerance to standard therapy (57 vs 62 percent).

However, response rates were lower among patients with cirrhosis vs those without (47 vs 66 percent; p=0.07).

Serious adverse events (AEs) were reported in three patients (2.7 percent), including one death. AEs resulted in treatment discontinuation in 10 patients (9.2 percent).

Used extensively in organ transplantation settings, MMF exerts selective antiproliferative effects on T- and B-lymphocytes by inhibiting DNA synthesis. Evidence shows that MMF is a good second-line agent for patients who fail to respond to or who cannot tolerate azathioprine. [J Clin Exp Hepatol 2014;4:221–22]

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Most Read Articles
24 Jun 2015
Persistent sleepless nights can take their toll on sufferers, and leave some insomniacs gasping for a caffeine hit just to get them through the morning slog.
01 Aug 2012

Proper use of family planning methods is the key to preventing unplanned preg­nancies. Despite the great effort spent in the research and development of contra­ceptive methods resulting in many new advances, none of the current methods is 100% effective. Emergency contraception (EC), also called ‘postcoital contraception’, is a back-up contraception adminis­tered to a woman after unprotected sexual intercourse (UPSI) or contraceptive failure, so as to prevent unplanned pregnancy. This may be indicated when unexpected intercourse has occurred without the use of any contraception, when there is a sus­pected potential failure of one’s regular contraceptive method (eg, condom break­age or slippage, missed dose of hormonal contraceptive, or potential failure of an intrauterine contraceptive device), or after sexual assault.

Roshini Claire Anthony, 27 Dec 2017

A once-daily subcutaneous dose of teriparatide may be more effective than once-weekly oral risedronate in preventing vertebral fractures in post-menopausal women with osteoporosis and a history of vertebral fractures, findings from the VERO* trial show.

Yesterday
Several adults who experienced a first-time myocardial infarction (MI) at a young age have been found to be ineligible for statin therapy based on current guideline-based treatment thresholds, reports a study, stressing the need for better risk assessment tools among young adults.