Most Read Articles
31 Jul 2018
New drug applications approved by US FDA as of 16 - 31 July 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Tristan Manalac, 16 Dec 2017
Methylphenidates, but not amphetamines, when taken during the first trimester of pregnancy, slightly increase the risk of cardiac congenital malformations, a recent study has shown.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.

Repeated vaccination effective in protecting against severe influenza

09 Jan 2018

Repeated influenza vaccination is effective in preventing severe vs nonsevere influenza infections in elderly adults, a recent multicentre, case-control study has shown.

The study included 130 and 598 patients with severe and nonsevere influenza, who were then matched to 333 and 1,493 controls, respectively.

Vaccination in the current season and at least one of the three previous seasons led to significantly lower odds of severe disease (adjusted odds ratio [OR], 0.45; 95 percent CI, 0.26–0.76; p=0.003), intensive care unit (ICU) admission (adjusted OR, 0.35; 0.17–0.70; p=0.003) and death (adjusted OR, 0.44; 0.23–0.86; p=0.02).

In comparison, those who were only vaccinated in the current season did not reduce risks of severe disease (adjusted OR, 2.22; 0.89–5.51; p=0.09) and ICU admissions (adjusted OR, 1.14; 0.34–3.87; p=0.8), and had significantly higher risk of death (adjusted OR, 3.35; 1.06–10.58; p=0.04).

Moreover, those who were unvaccinated were admitted to the ICU more frequently (16 vs 6 percent; p<0.001) compared with those who were vaccinated. Mortality rates within the first 30 days after admission were also higher in unvaccinated participants (14 vs 9 percent; p=0.04).

In terms of hospital admissions, those who were vaccinated in the current season and in any of the three previous seasons were less likely to be admitted to the hospital for nonsevere influenza (31 percent effectiveness). Effectiveness estimates were higher for preventing ICU admission (74 percent) and death (70 percent).

Furthermore, those who were vaccinated in the current season only were not significantly protected against severe influenza.

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Most Read Articles
31 Jul 2018
New drug applications approved by US FDA as of 16 - 31 July 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Tristan Manalac, 16 Dec 2017
Methylphenidates, but not amphetamines, when taken during the first trimester of pregnancy, slightly increase the risk of cardiac congenital malformations, a recent study has shown.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.