Most Read Articles
2 days ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 6 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
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Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
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Repeat imaging of sacroiliac joints not useful in diagnostic workup of axSpA

01 Oct 2018

The usefulness of repeating magnetic resonance imaging (MRI) of the sacroiliac joints (MRI-SI) after 3 months or 1 year in the diagnostic workup of chronic back pain patients suspected of axial spondyloarthritis (axSpA) appears to be limited, according to data from the SPACE cohort. Specifically, only a small percentage of patients exhibit changes in MRI-SI status.

A total of 188 patients with chronic back pain (mean age 31.0 years; 38.3 percent male; symptom duration, 13.2 months) underwent evaluation of all SpA‐features and repeated MRI‐SI at baseline, 3 months and 1 year. Thirty-one patients (16.5 percent) were MRI‐SI‐positive at baseline. MRI‐SI positivity was evaluated according to Assessment of SpondyloArthritis International Society (ASAS).

MRI-SI status changed from positive to negative in 3/27 patients (11.1 percent) after 3 months and in 11/29 patients (37.9 percent) after 1 year. This change was partly induced by antitumour necrosis factor therapy initiation.

On the other hand, status changed from negative to positive in 5/116 patients (4.3 percent) after 3 months and in 10/138 patients (7.2 percent) after 1 year.

On generalized estimating equation analysis, HLA‐B27‐positivity and male gender emerged as independent determinants of a positive MRI-SI at any time point (42 percent in HLA‐B27-positive males; 6 percent in HLA‐B27-negative females).

Meanwhile, MRI-SI status at baseline strongly predicted MRI-SI status at follow-up, such that a negative status at baseline predicted a very low likelihood of a positive MRI during follow‐up (max, 7 percent).

The present data suggest that the usefulness of repeating a negative MRI in terms of diagnostic yield is low, although there are different risks related to sex and HLA-B27 status, researchers said.

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Most Read Articles
2 days ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 6 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
3 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
3 days ago
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.