Most Read Articles
Stephen Padilla, 6 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
6 days ago
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 2 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.

Renin-angiotensin system components enriched in RA vs OA patients

14 Jan 2020

Components of the renin-angiotensin system (RAS), such as renin, angiotensin-converting enzyme (ACE), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), are more elevated in the synovial fluid of patients with rheumatoid arthritis (RA) than with osteoarthritis (OA), a recent study has shown.

The study included 34 RA (mean age, 54.11±4.08 years) and 41 OA (mean age, 67.09±3.92 years) patients. Enzyme-linked immunosorbent assays were used to measure the levels of ACE, VEGF, renin and MMP-13 in synovial fluid samples. Quantitative real-time polymerase chain reaction, along with western blot analysis and immunohistochemistry, was used to quantify expression of pertinent receptors.

Expression levels of renin, as well as ACE and its type 1 and 2 receptors, were significantly enriched in RA vs OA patients (p<0.05 for mRNA and protein). The same was true for VEGF and MMP-13 expression (p<0.05).

This enrichment was also reflected in the concentration of the markers in synovial fluid samples. Renin, for example, was present in much higher levels in RA than in OA patients (13.36±4.72 vs 4.81±1.98 pg/mL; p<0.001), as was ACE (50.79±15.30 vs 26.26±10.15 ng/mL; p<0.001). MMP-13 (412.72±145.31 vs 154.58±66.91 pg/mL; p<0.001) and VEGF (600.06±90.98 vs 224.99±73.09 pg/mL; p<0.001) were similarly more concentrated in RA synovial fluid.

“These results suggest that RAS-related components and MMP-13 may be therapeutic targets for inhibiting angiogenesis and may be new strategies for the treatment of RA and OA,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 6 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
6 days ago
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 2 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.