Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Renin-angiotensin system components enriched in RA vs OA patients

14 Jan 2020

Components of the renin-angiotensin system (RAS), such as renin, angiotensin-converting enzyme (ACE), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), are more elevated in the synovial fluid of patients with rheumatoid arthritis (RA) than with osteoarthritis (OA), a recent study has shown.

The study included 34 RA (mean age, 54.11±4.08 years) and 41 OA (mean age, 67.09±3.92 years) patients. Enzyme-linked immunosorbent assays were used to measure the levels of ACE, VEGF, renin and MMP-13 in synovial fluid samples. Quantitative real-time polymerase chain reaction, along with western blot analysis and immunohistochemistry, was used to quantify expression of pertinent receptors.

Expression levels of renin, as well as ACE and its type 1 and 2 receptors, were significantly enriched in RA vs OA patients (p<0.05 for mRNA and protein). The same was true for VEGF and MMP-13 expression (p<0.05).

This enrichment was also reflected in the concentration of the markers in synovial fluid samples. Renin, for example, was present in much higher levels in RA than in OA patients (13.36±4.72 vs 4.81±1.98 pg/mL; p<0.001), as was ACE (50.79±15.30 vs 26.26±10.15 ng/mL; p<0.001). MMP-13 (412.72±145.31 vs 154.58±66.91 pg/mL; p<0.001) and VEGF (600.06±90.98 vs 224.99±73.09 pg/mL; p<0.001) were similarly more concentrated in RA synovial fluid.

“These results suggest that RAS-related components and MMP-13 may be therapeutic targets for inhibiting angiogenesis and may be new strategies for the treatment of RA and OA,” said researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.