Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

Yesterday
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
2 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, Yesterday
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.

Renal transplant improves survival among lupus nephritis patients with ESRD

08 Feb 2019
Hospital Authority is set to introduce a pair exchange scheme for kidney transplants by the second half of 2018.

Renal transplantation confers survival benefits to patients with end-stage renal disease (ESRD) due to lupus nephritis (LN), driven primarily by reduced deaths from cardiovascular disease and infection, a study has shown.

“The findings highlight the benefit of timely referral for transplant to improve outcomes in this population,” the investigators said.

Of the 9,659 patients with LN-ESRD who were waitlisted for a renal transplant during the study period, 5,738 (59 percent) had a transplant. Most patients were female (82 percent) and nonwhite (60 percent).

Among waitlisted patients, an association was found between transplant and reduced all-cause mortality (adjusted hazard ratio [HR], 0.30; 95 percent CI, 0.270.33). Adjusted HRs for cause-specific mortality were as follows: 0.26 (0.23‒0.30) for cardiovascular disease, 0.30 (0.19‒0.48) for coronary heart disease, 0.41 (0.32‒0.52) for infection and 0.41 (0.31‒0.53) for sepsis.

To examine the potential effect of renal transplant on survival, this nationwide cohort study enrolled patients with incident LN-ESRD who were waitlisted for a renal transplant. Analysis was conducted on first renal transplant as a time-varying exposure.

All-cause and cause-specific mortality were the primary outcomes. The investigators used time-dependent Cox regression analysis to estimate the HR of these outcomes associated with renal transplant in the primary analysis. Sequential cohort matching was used in a secondary analysis limited to patients with Medicare, which allowed assessment of time-varying covariates.

The study was limited by unmeasured factors that could have contributed to the observed associations. However, the E-value analysis suggested robustness of the findings, according to the investigators.

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

Yesterday
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
2 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, Yesterday
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.