Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Renal transplant improves survival among lupus nephritis patients with ESRD

08 Feb 2019
Hospital Authority is set to introduce a pair exchange scheme for kidney transplants by the second half of 2018.

Renal transplantation confers survival benefits to patients with end-stage renal disease (ESRD) due to lupus nephritis (LN), driven primarily by reduced deaths from cardiovascular disease and infection, a study has shown.

“The findings highlight the benefit of timely referral for transplant to improve outcomes in this population,” the investigators said.

Of the 9,659 patients with LN-ESRD who were waitlisted for a renal transplant during the study period, 5,738 (59 percent) had a transplant. Most patients were female (82 percent) and nonwhite (60 percent).

Among waitlisted patients, an association was found between transplant and reduced all-cause mortality (adjusted hazard ratio [HR], 0.30; 95 percent CI, 0.270.33). Adjusted HRs for cause-specific mortality were as follows: 0.26 (0.23‒0.30) for cardiovascular disease, 0.30 (0.19‒0.48) for coronary heart disease, 0.41 (0.32‒0.52) for infection and 0.41 (0.31‒0.53) for sepsis.

To examine the potential effect of renal transplant on survival, this nationwide cohort study enrolled patients with incident LN-ESRD who were waitlisted for a renal transplant. Analysis was conducted on first renal transplant as a time-varying exposure.

All-cause and cause-specific mortality were the primary outcomes. The investigators used time-dependent Cox regression analysis to estimate the HR of these outcomes associated with renal transplant in the primary analysis. Sequential cohort matching was used in a secondary analysis limited to patients with Medicare, which allowed assessment of time-varying covariates.

The study was limited by unmeasured factors that could have contributed to the observed associations. However, the E-value analysis suggested robustness of the findings, according to the investigators.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.