Most Read Articles
3 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
6 days ago
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Roshini Claire Anthony, 2 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.

Renal transplant improves survival among lupus nephritis patients with ESRD

08 Feb 2019
Hospital Authority is set to introduce a pair exchange scheme for kidney transplants by the second half of 2018.

Renal transplantation confers survival benefits to patients with end-stage renal disease (ESRD) due to lupus nephritis (LN), driven primarily by reduced deaths from cardiovascular disease and infection, a study has shown.

“The findings highlight the benefit of timely referral for transplant to improve outcomes in this population,” the investigators said.

Of the 9,659 patients with LN-ESRD who were waitlisted for a renal transplant during the study period, 5,738 (59 percent) had a transplant. Most patients were female (82 percent) and nonwhite (60 percent).

Among waitlisted patients, an association was found between transplant and reduced all-cause mortality (adjusted hazard ratio [HR], 0.30; 95 percent CI, 0.270.33). Adjusted HRs for cause-specific mortality were as follows: 0.26 (0.23‒0.30) for cardiovascular disease, 0.30 (0.19‒0.48) for coronary heart disease, 0.41 (0.32‒0.52) for infection and 0.41 (0.31‒0.53) for sepsis.

To examine the potential effect of renal transplant on survival, this nationwide cohort study enrolled patients with incident LN-ESRD who were waitlisted for a renal transplant. Analysis was conducted on first renal transplant as a time-varying exposure.

All-cause and cause-specific mortality were the primary outcomes. The investigators used time-dependent Cox regression analysis to estimate the HR of these outcomes associated with renal transplant in the primary analysis. Sequential cohort matching was used in a secondary analysis limited to patients with Medicare, which allowed assessment of time-varying covariates.

The study was limited by unmeasured factors that could have contributed to the observed associations. However, the E-value analysis suggested robustness of the findings, according to the investigators.

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Most Read Articles
3 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
6 days ago
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Roshini Claire Anthony, 2 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.