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Renal replacement therapy tied to worse sexual dysfunction

13 Dec 2020

Sexual dysfunction (SD) is worse among patients with chronic renal failure (CRF) receiving renal replacement therapy, reports a new meta-analysis.

A search of online databases yielded 10 studies eligible for quantitative analysis, totalling 3,725 participants, 737 of whom were CRF patients undergoing renal replacement therapy. Six of the included studies were case-control in design; five studies looked into female SD (FSD) as an outcome, four considered erectile dysfunction (ED), and one reported both.

Pooled analysis revealed that renal replacement therapy in CRF patients significantly increased the risk of FSD (relative risk [RR], 2.07, 95 percent confidence interval [CI], 1.47–2.91; p=0.000) and ED (RR, 2.95, 95 percent CI, 2.16–4.02; p=0.000). In both analyses, heterogeneity of evidence was significant (p=0.000 for both).

Stratifying according to the different types of renal replacement therapy, the researchers found that peritoneal dialysis (RR, 2.33, 95 percent CI, 1.29–4.21; p=0.000) and haemodialysis (RR, 2.23, 95 percent CI, 1.52–3.28; p=0.000) were stronger risk factors for FSD than renal transplant (RR, 1.80, 95 percent CI, 1.04–3.12; p=0.000).

In men, peritoneal dialysis (RR, 8.00, 95 percent CI, 5.69–11.25; p=0.000), haemodialysis (RR, 3.03, 95 percent CI, 2.20–4.17; p=0.000), and renal transplant (RR, 3.58, 95 percent CI, 1.45–8.83; p=0.000) all worsened ED risk relative to controls.

“Given its association with SD, in clinical practice, the assessment of sexual function and specific treatments are necessary for patients receiving renal replacement therapy to improve the quality of life,” the researchers said.

“However, this evidence was derived from limited studies. Further high-quality, prospective, multicentre studies with long follow-up time are still needed to confirm our result,” they added.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.