Most Read Articles
Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Renal function linked to choroidal thickness in retinal vein occlusion

6 days ago

Renal function appears to impact subfoveal choroidal thickness (SFChT) in treatment-naïve eyes with retinal vein occlusion (RVO), a recent study has found.

Through a retrospective chart review, the researchers looked at renal function information of 56 patients (mean age, 58.8±11.9 years) with unilateral RVO, such as estimated glomerular filtration rate (eGFR), blood urea nitrogen, and creatinine levels. SFChT was measured using ocular coherence tomography (OCT).

Central and mean retinal thickness (RT) were both significantly higher in RVO eyes compared with normal fellow eyes (p<0.001 for both), as was SFChT (316.1±101.3 vs 290.8±100.5 µm; p=0.015). Mean ChT was likewise greater in RVO eyes (p=0.014).

When compared against normal control eyes, RVO eyes also showed significantly higher central and mean RT (p<0.001 for both). However, SFChT (p=0.167) and mean ChT (p=0.280) were not significantly altered.

Simple linear regression analysis revealed that SFChT was significantly correlated with eGFR (β, 1.393; p<0.001). This interaction remained significant in multiple linear regression analysis even after adjustments for covariates (β, 1.391; p<0.001).

Creatinine (p=0.002) and phosphorous (p=0.016) levels were likewise significant renal correlates of SFChT, although their effects were attenuated after adjustments.

“In this study, we evaluated the correlation of renal function with choroidal thickness using swept-source OCT. This study revealed that choroid thickness was closely correlated with eGFR in patients with RVO, independently of age and other potentially confounding factors,” the researchers said.

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Most Read Articles
Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.