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Renal function linked to choroidal thickness in retinal vein occlusion

18 Oct 2020

Renal function appears to impact subfoveal choroidal thickness (SFChT) in treatment-naïve eyes with retinal vein occlusion (RVO), a recent study has found.

Through a retrospective chart review, the researchers looked at renal function information of 56 patients (mean age, 58.8±11.9 years) with unilateral RVO, such as estimated glomerular filtration rate (eGFR), blood urea nitrogen, and creatinine levels. SFChT was measured using ocular coherence tomography (OCT).

Central and mean retinal thickness (RT) were both significantly higher in RVO eyes compared with normal fellow eyes (p<0.001 for both), as was SFChT (316.1±101.3 vs 290.8±100.5 µm; p=0.015). Mean ChT was likewise greater in RVO eyes (p=0.014).

When compared against normal control eyes, RVO eyes also showed significantly higher central and mean RT (p<0.001 for both). However, SFChT (p=0.167) and mean ChT (p=0.280) were not significantly altered.

Simple linear regression analysis revealed that SFChT was significantly correlated with eGFR (β, 1.393; p<0.001). This interaction remained significant in multiple linear regression analysis even after adjustments for covariates (β, 1.391; p<0.001).

Creatinine (p=0.002) and phosphorous (p=0.016) levels were likewise significant renal correlates of SFChT, although their effects were attenuated after adjustments.

“In this study, we evaluated the correlation of renal function with choroidal thickness using swept-source OCT. This study revealed that choroid thickness was closely correlated with eGFR in patients with RVO, independently of age and other potentially confounding factors,” the researchers said.

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Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
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Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

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