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Renal function linked to choroidal thickness in retinal vein occlusion

18 Oct 2020

Renal function appears to impact subfoveal choroidal thickness (SFChT) in treatment-naïve eyes with retinal vein occlusion (RVO), a recent study has found.

Through a retrospective chart review, the researchers looked at renal function information of 56 patients (mean age, 58.8±11.9 years) with unilateral RVO, such as estimated glomerular filtration rate (eGFR), blood urea nitrogen, and creatinine levels. SFChT was measured using ocular coherence tomography (OCT).

Central and mean retinal thickness (RT) were both significantly higher in RVO eyes compared with normal fellow eyes (p<0.001 for both), as was SFChT (316.1±101.3 vs 290.8±100.5 µm; p=0.015). Mean ChT was likewise greater in RVO eyes (p=0.014).

When compared against normal control eyes, RVO eyes also showed significantly higher central and mean RT (p<0.001 for both). However, SFChT (p=0.167) and mean ChT (p=0.280) were not significantly altered.

Simple linear regression analysis revealed that SFChT was significantly correlated with eGFR (β, 1.393; p<0.001). This interaction remained significant in multiple linear regression analysis even after adjustments for covariates (β, 1.391; p<0.001).

Creatinine (p=0.002) and phosphorous (p=0.016) levels were likewise significant renal correlates of SFChT, although their effects were attenuated after adjustments.

“In this study, we evaluated the correlation of renal function with choroidal thickness using swept-source OCT. This study revealed that choroid thickness was closely correlated with eGFR in patients with RVO, independently of age and other potentially confounding factors,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
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Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.