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Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
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Renal disease among diabetics heterogenous

09 Oct 2019

In diabetic adults, the presentation of renal disease is heterogenous and involves different mechanisms of action, a new Japan study has found.

Drawing data from 355 patients with type 1 diabetes and 5,194 with type 2 diabetes, researchers determined the prevalence of renal dysfunction and albuminuria, as well as related factors. Those undergoing dialysis, with malignant disease or who had proliferative diabetic retinopathy were ineligible.

Of the type 1 diabetes participants, majority (n=290; mean age, 56±9 years; 43.4 percent male) had normal urinary albumin levels, while 65 (mean age, 58±8 years; 46.2 percent male) were either micro- or macroalbuminuric. In those with type 2 disease, 3,631 (mean age, 61±8 years; 59.0 percent male) were normoalbuminuric while 1,563 (mean age, 62±8 years 59.4 percent male) had abnormal levels of albumin in the urine.

Renal dysfunction, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2, without albuminuria was present in 7.3 percent and 9.0 percent of type 1 and 2 diabetes patients, respectively.

Logistic regression analysis further found that in type 1 diabetes, the duration of the endocrinal disease (p=0.009) and the presence of or a history of hypertension (p=0.005) were significant indicators of albuminuria, while age (p<0.001) and disease duration (p=0.023) were significantly correlated with lowered eGFR.

In type 2 diabetes, on the other hand, significant predictors of albuminuria were age (p=0.017), duration of diabetes (p<0.001), the presence of or a history of hypertension (p<0.001), body mass index (p<0.001), glycated haemoglobin (p<0.001), and eGFR (p<0.001). The male sex (p<0.001), age (p<0.001), albuminuria (p<0.001) and regular alcohol intake (p<0.001) were all associated with renal dysfunction.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
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While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.