Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 4 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.

4 days ago
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.

Renal disease among diabetics heterogenous

09 Oct 2019

In diabetic adults, the presentation of renal disease is heterogenous and involves different mechanisms of action, a new Japan study has found.

Drawing data from 355 patients with type 1 diabetes and 5,194 with type 2 diabetes, researchers determined the prevalence of renal dysfunction and albuminuria, as well as related factors. Those undergoing dialysis, with malignant disease or who had proliferative diabetic retinopathy were ineligible.

Of the type 1 diabetes participants, majority (n=290; mean age, 56±9 years; 43.4 percent male) had normal urinary albumin levels, while 65 (mean age, 58±8 years; 46.2 percent male) were either micro- or macroalbuminuric. In those with type 2 disease, 3,631 (mean age, 61±8 years; 59.0 percent male) were normoalbuminuric while 1,563 (mean age, 62±8 years 59.4 percent male) had abnormal levels of albumin in the urine.

Renal dysfunction, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2, without albuminuria was present in 7.3 percent and 9.0 percent of type 1 and 2 diabetes patients, respectively.

Logistic regression analysis further found that in type 1 diabetes, the duration of the endocrinal disease (p=0.009) and the presence of or a history of hypertension (p=0.005) were significant indicators of albuminuria, while age (p<0.001) and disease duration (p=0.023) were significantly correlated with lowered eGFR.

In type 2 diabetes, on the other hand, significant predictors of albuminuria were age (p=0.017), duration of diabetes (p<0.001), the presence of or a history of hypertension (p<0.001), body mass index (p<0.001), glycated haemoglobin (p<0.001), and eGFR (p<0.001). The male sex (p<0.001), age (p<0.001), albuminuria (p<0.001) and regular alcohol intake (p<0.001) were all associated with renal dysfunction.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 4 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.

4 days ago
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.