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Renal disease among diabetics heterogenous

09 Oct 2019

In diabetic adults, the presentation of renal disease is heterogenous and involves different mechanisms of action, a new Japan study has found.

Drawing data from 355 patients with type 1 diabetes and 5,194 with type 2 diabetes, researchers determined the prevalence of renal dysfunction and albuminuria, as well as related factors. Those undergoing dialysis, with malignant disease or who had proliferative diabetic retinopathy were ineligible.

Of the type 1 diabetes participants, majority (n=290; mean age, 56±9 years; 43.4 percent male) had normal urinary albumin levels, while 65 (mean age, 58±8 years; 46.2 percent male) were either micro- or macroalbuminuric. In those with type 2 disease, 3,631 (mean age, 61±8 years; 59.0 percent male) were normoalbuminuric while 1,563 (mean age, 62±8 years 59.4 percent male) had abnormal levels of albumin in the urine.

Renal dysfunction, defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2, without albuminuria was present in 7.3 percent and 9.0 percent of type 1 and 2 diabetes patients, respectively.

Logistic regression analysis further found that in type 1 diabetes, the duration of the endocrinal disease (p=0.009) and the presence of or a history of hypertension (p=0.005) were significant indicators of albuminuria, while age (p<0.001) and disease duration (p=0.023) were significantly correlated with lowered eGFR.

In type 2 diabetes, on the other hand, significant predictors of albuminuria were age (p=0.017), duration of diabetes (p<0.001), the presence of or a history of hypertension (p<0.001), body mass index (p<0.001), glycated haemoglobin (p<0.001), and eGFR (p<0.001). The male sex (p<0.001), age (p<0.001), albuminuria (p<0.001) and regular alcohol intake (p<0.001) were all associated with renal dysfunction.

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Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 2 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.