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Pearl Toh, 2 days ago
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Relapse may contribute to antipsychotic treatment resistance

03 Dec 2018

Relapse following effective treatment of the first episode of schizophrenia may reduce or delay antipsychotic treatment response, a recent study has shown.

Patients with a diagnosis of first-episode schizophrenia or schizoaffective disorder who met the following criteria were included: referral to the First-Episode Psychosis Program between 2003 and 2013; treatment with an oral second-generation antipsychotic according to a standardized treatment algorithm; positive symptom remission; subsequent relapse (ie, second episode) in association with nonadherence; and reintroduction of antipsychotic treatment with the same agent used to achieve response in the first episode.

Outcomes used as an index of antipsychotic treatment response were as follows: changes in the brief psychiatric rating scale total and positive symptom scores and number of patients who achieved positive symptom remission and 20- and 50-percent response.

One hundred thirty patients were analysed, and all of them took the same antipsychotic drug in both episodes. However, significant episode-by-time interactions occurred for all outcomes of antipsychotic treatment response over 1 year in favour of the first vs the second episode (50-percent response rate: 48.7 percent vs 10.4 percent at week 7; 88.2 percent vs 27.8 percent at week 27, respectively).

There were significantly higher antipsychotic doses in the second vs the first episode, but the results remained unchanged after adjusting for antipsychotic dose.

“Although some studies have suggested that relapse may be associated with antipsychotic treatment resistance in schizophrenia, the number and quality of studies is limited,” the investigators noted.

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Most Read Articles
Pearl Toh, 2 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.