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Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

Regular moderate exercise helps ward off frailty among older adults

25 Apr 2020

Regular physical activity (PA) may help decrease the risk of physical, psychological and social frailty among older adults, a recent study has found.

Researchers conducted a longitudinal cohort analysis of 1,735 community-dwelling elderly adults (mean age, 79.6±5.5 years; 61.1 percent female). The frequency of moderate PA at enrolment was self-reported and categorized as regular or low frequency. The patterns of change in frequency over 12 months was classified into four: continued regular frequency, decreased frequency, continued low frequency and increased frequency.

At baseline, the overall frailty scores, as assessed according the Tilburg Frailty Indicator, were 4.45±2.91 and 6.69±3.07 in participants who had regular and low frequencies of moderate PA, respectively. At the 12-month follow-up, the corresponding scores changed to 4.56±3.16 and 6.80±3.27.

In terms of PA changes over time, those who maintained their frequent moderate PA habit were the least frail, while those who continued to engage in moderate PA at low frequencies were the frailest. Those who started doing moderate PA more over time became less frail than they were at baseline. The opposite was true for those who scaled back.

This was confirmed in multivariate linear regression models. Relative to those who were consistent with regular moderate PA, those whose exercise frequencies dropped (B, 1.31, 95 percent confidence interval [CI], 0.99–1.63; p<0.001) and who continued to exercise infrequently (B, 1.16, 95 percent CI, 0.84–1.49; p<0.001) were significantly more likely to be frail.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.