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20 Jun 2020
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Regular consumption of tofu, soy protein may lower T2D risk

01 Apr 2020

Higher intakes of tofu, soy protein and soy isoflavones, but not total legumes or total soy, appear to reduce the risk of developing type 2 diabetes (T2D), suggests a study.

Relevant prospective cohort studies were searched up to August 2019 in the following databases: PubMed, Embase and Ovid. The investigators pooled study-specific, multivariable-adjusted relative risk (RR) and 95 percent confidence intervals (CIs).

Fifteen unique cohorts were identified, including 565,810 individuals and 32,093 incident cases. The summary RRs of incident T2D were as follows: 0.95 (95 percent CI, 0.79–1.14) for total legumes, 0.83 (95 percent CI, 0.68–1.01) for total soy, 0.89 (95 percent CI, 0.71–1.11) for soy milk, 0.92 (95 percent CI, 0.84–0.99) for tofu, 0.84 (95 percent CI, 0.75–0.95) for soy protein, and 0.88 (95 percent CI, 0.81–0.96) for soy isoflavones.

There was high heterogeneity for total legumes (I2, 84.8 percent), total soy (I2, 90.8 percent) and soy milk (I2, 91.7 percent). Potential sources of heterogeneity for total legume or soy milk were not clear. However, heterogeneity for total soy was predicted by geographic location (Asia, US; p=0.04) and study quality (high, moderate or low; p=0.02).

Dose–response analysis revealed significant linear inverse associations for tofu, soy protein and soy isoflavones (pall<0.05). Overall quality of evidence was moderate for total legumes and low for total soy and soy subtypes.

“Our findings support recommendations to increase intakes of certain soy products for the prevention of T2D,” the authors said. “However, the overall quality of evidence was low and more high-quality evidence from prospective studies is needed.“

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.