Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.

Regular consumption of fish may protect against colorectal cancer

21 Mar 2020

Eating fish at recommended levels helps reduce the risk of developing colorectal cancer, possibly through exposure to long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs), a study has found.

A total of 521,324 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study completed food frequency questionnaires to estimate dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA.

There were 6,291 individuals who developed CRC over a median follow up of 14.9 years. Of these cases, 4,197 were colon cancers and 2,094 cases were rectal cancers. Compared with noncancer controls, those who developed the malignancy were more likely to be current or former smokers and have higher consumption of red and processed meats and alcohol.

In multivariable Cox proportional hazards models, increased consumption of fish was protective against the risk of incident CRC. The hazard ratios (HRs) associated with the highest vs lowest quintile of intake was 0.88 (95 percent confidence interval [CI], 0.80–0.96; ptrend=0.005) for total fish, 0.90 (95 percent CI, 0.82–0.98; ptrend=0.009) for fatty fish, and 0.91 (95 percent CI, 0.83–1.00; ptrend=0.016) for lean fish.

In a subgroup of 461 CRC patients and 461 matched noncancer controls, elevated plasma phospholipid n-3 LC-PUFA levels likewise had a risk-reduction effect (highest vs lowest quintile of n-3 LC-PUFA concentration: HR, 0.86, 95 percent CI, 0.78–0.95; ptrend=0.010). Meanwhile, a dietary ratio of n-6:n-3 LC-PUFA was associated with an increased risk of CRC (quintile 5 vs 1: HR, 1.31, 95 percent CI, 1.18–1.45; ptrend<0.001).

The present data contribute to the growing body of evidence linking fish consumption to potentially lower risk of CRC, researchers said.

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Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.