Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Regular consumption of fish may protect against colorectal cancer

21 Mar 2020

Eating fish at recommended levels helps reduce the risk of developing colorectal cancer, possibly through exposure to long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs), a study has found.

A total of 521,324 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study completed food frequency questionnaires to estimate dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA.

There were 6,291 individuals who developed CRC over a median follow up of 14.9 years. Of these cases, 4,197 were colon cancers and 2,094 cases were rectal cancers. Compared with noncancer controls, those who developed the malignancy were more likely to be current or former smokers and have higher consumption of red and processed meats and alcohol.

In multivariable Cox proportional hazards models, increased consumption of fish was protective against the risk of incident CRC. The hazard ratios (HRs) associated with the highest vs lowest quintile of intake was 0.88 (95 percent confidence interval [CI], 0.80–0.96; ptrend=0.005) for total fish, 0.90 (95 percent CI, 0.82–0.98; ptrend=0.009) for fatty fish, and 0.91 (95 percent CI, 0.83–1.00; ptrend=0.016) for lean fish.

In a subgroup of 461 CRC patients and 461 matched noncancer controls, elevated plasma phospholipid n-3 LC-PUFA levels likewise had a risk-reduction effect (highest vs lowest quintile of n-3 LC-PUFA concentration: HR, 0.86, 95 percent CI, 0.78–0.95; ptrend=0.010). Meanwhile, a dietary ratio of n-6:n-3 LC-PUFA was associated with an increased risk of CRC (quintile 5 vs 1: HR, 1.31, 95 percent CI, 1.18–1.45; ptrend<0.001).

The present data contribute to the growing body of evidence linking fish consumption to potentially lower risk of CRC, researchers said.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.