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Regular coffee consumption helps maintain kidney health

17 May 2020

Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate (eGFR) and confers protection against the risk of chronic kidney disease (CKD) stages G3–G5 and albuminuria, as shown in a study.

Researchers included 227,666 participants from the UK Biobank for a genome-wide association study (GWAS) and 133,814 participants (12,385 with CKD) from the CKDGen Consortium for a Mendelian randomization (MR) analysis of kidney outcomes.

In the UK Biobank GWAS, 2,126 single-nucleotide polymorphisms (SNPs) were associated with coffee consumption (p<5 × 10−8), of which 25 were independent and available in the CKDGen GWAS.

MR analysis revealed that drinking an extra cup of coffee per day exerted a protective effect on CKD stages G3–G5 (eGFR < 60 mL/min/1.73 m2; odds ratio [OR], 0.84, 95 percent confidence interval [CI], 0.72–0.98; p=0.03) and albuminuria (OR, 0.81, 95 percent CI, 0.67–0.97; p=0.02).

An extra coffee cup daily was also associated with higher eGFR (p=1.6 × 10−6) after removal of three SNPs responsible for significant heterogeneity (Cochran Q, p=3.5 × 10−15).

The present data highlight a potential protective role of coffee in maintaining kidney health among regular drinkers, according to the researchers. This has important implications in view of the increasing burden of CKD worldwide, as well as in the context of a lack of effective interventions to prevent eGFR decline in populations with and without CKD.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.