Regression of cervical intraepithelial neoplasia higher in younger women
Regression rates of cervical intraepithelial neoplasia (CIN) appear to be significantly elevated in younger females, a recent study has shown. Moreover, the effect of age is independent of risk of human papillomavirus (HPV) and CIN grade.
In the study cohort of 783 females, rates of regression were highest in those aged <25 years (n=141; 44.68 percent) and decreased to 33.71 percent in those aged ≥25 to <30 years (n=178). Regression rates continued to drop as age increased: ≥30 to <35 years (n=152; 30.92 percent), ≥35 to <40 years (n=139; 27.34 percent) and ≥40 years (n=173; 24.85 percent; p<0.001 for trend).
Similarly, complete remission was highest in the youngest age group (39.72 percent) and decreased significantly with increasing age (≥25 to <30 years: 29.21 percent; ≥30 to <35 years: 25.66 percent; ≥35 to <40 years: 22.30 percent; ≥40 years: 23.12 percent; p<0.001 for trend).
Disease progression showed the inverse trend: rates were highest in the ≥40 years age group (24.86 percent) and decreased with age; only 10.64 percent of the participants <25 years of age showed progression (p=0.003 for trend).
Multivariable logistic regression confirmed the above trends. Per 5-year increase in age, there was a significant 11-percent decrease in the likelihood of regression (odds ratio, 0.89; 95 percent CI, 0.79–0.99; p=0.049). This association was independent of CIN grade and HPV high-risk infection status.
“Observational management should be considered for selected young women who plan future childbearing,” said researchers.