Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 5 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
5 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.

Regression of cervical intraepithelial neoplasia higher in younger women

02 May 2018

Regression rates of cervical intraepithelial neoplasia (CIN) appear to be significantly elevated in younger females, a recent study has shown. Moreover, the effect of age is independent of risk of human papillomavirus (HPV) and CIN grade.

In the study cohort of 783 females, rates of regression were highest in those aged <25 years (n=141; 44.68 percent) and decreased to 33.71 percent in those aged ≥25 to <30 years (n=178). Regression rates continued to drop as age increased: ≥30 to <35 years (n=152; 30.92 percent), ≥35 to <40 years (n=139; 27.34 percent) and ≥40 years (n=173; 24.85 percent; p<0.001 for trend).

Similarly, complete remission was highest in the youngest age group (39.72 percent) and decreased significantly with increasing age (≥25 to <30 years: 29.21 percent; ≥30 to <35 years: 25.66 percent; ≥35 to <40 years: 22.30 percent; ≥40 years: 23.12 percent; p<0.001 for trend).

Disease progression showed the inverse trend: rates were highest in the ≥40 years age group (24.86 percent) and decreased with age; only 10.64 percent of the participants <25 years of age showed progression (p=0.003 for trend).

Multivariable logistic regression confirmed the above trends. Per 5-year increase in age, there was a significant 11-percent decrease in the likelihood of regression (odds ratio, 0.89; 95 percent CI, 0.79–0.99; p=0.049). This association was independent of CIN grade and HPV high-risk infection status.

“Observational management should be considered for selected young women who plan future childbearing,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 5 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
5 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.