Most Read Articles
Dr Margaret Shi, 13 Jul 2020

An MRI-first diagnostic pathway, combined with risk-tailored screening, is shown to improve the benefit-to-harm profile and cost-effectiveness of screening for prostate cancer (PCa), according to results of a recent lifetable modelling study presented at AACR 2020 Virtual Meeting II.

Christina Lau, 14 Jul 2020

Flat-dose nivolumab, administered as a 30-minute infusion, is well tolerated and active in Asian patients with previously treated advanced non-small-cell lung cancer (NSCLC), according to results of the phase IIIb CheckMate 870 study.

Natalia Reoutova, 17 Jul 2020

At a median follow-up of 22.9 months, atezolizumab plus carboplatin and etoposide (CP/ET), given as a first-line treatment, continued to demonstrate an improvement in overall survival (OS) vs placebo plus CP/ET in patients with extensive-stage small-cell lung cancer (ES-SCLC), according to updated results of the IMpower133 trial presented at the American Association for cancer Research (AACR) 2020 Virtual Annual Meeting II.

12 Jun 2020
Drawing from experience as a key investigator in landmark clinical trials (including PALOMA, MONALEESA and MONARCH), and his clinical experience with CDK4/6 inhibitors, Dr Rafael Villanueva Vázquez shares his insights into the current evidence of using CDK4/6 inhibitors to treat HR+/HER2- ABC.

Regorafenib a promising treatment for metastatic colorectal cancer

Tristan Manalac
26 Nov 2017

Regorafenib appears to have promising efficacy as a third- or fourth-line treatment for patients with metastatic colorectal cancer (mCRC), according to a new study from Macau presented at the recently concluded European Society for Medical Oncology Asia 2017 Congress (ESMO Asia 2017).

The research team performed a retrospective review of the medical records of 36 mCRC patients (median age 58 years; 53 percent male) who received regorafenib monotherapy. All participants had prior palliative chemotherapy treatment regimens containing oxaliplatin, irinotecan and fluorouracil with biologics such as bevacizumab or cetuximab.

Majority of the patients were administered regorafenib at 160 mg/day (41 percent), while the others received a daily dose of 120 mg (28 percent) or 80 mg (31 percent).

Of the 36 participants, 45 percent had one to two prior lines of mCRC treatment, 34 percent had three and 21 percent had at least four; 90 percent received prior targeted therapies. Colon cancer was reported in 30, while the remaining 6 had rectal cancer. [ESMO Asia, abstract 152P]

Over a median treatment duration of 4.5 months, 17 patients achieved disease control corresponding to a rate of 47.2 percent.

Compared with those who did not receive the drug, those treated with third- or fourth-line regorafenib had longer median overall survival after the failure of standardized treatment (3.8 vs 8.0 months).

Overall survival from the diagnosis of unresectable mCRC following curative resection was likewise longer for those who were administered regorafenib than for those who were not (18.9 vs 34.9 months).

In the study sample, the most common adverse event was any grade of hand-foot-skin reaction, observed in 69.4 percent of the participants; grade 3 of this adverse event was observed in 30.5 percent. This was followed by fatigue (41.6 percent), liver function abnormalities (38.9 percent), mucositis (36.1 percent), rashes (36.1 percent), diarrhoea (33.3 percent) and hyperbilirubinemia (27.7 percent).

Other adverse events included bleeding (5.6 percent), hypertension (16.6 percent), nausea (16.9 percent) and anorexia (22.2 percent).

There were four grade 4 adverse events: elevated aspartate transaminase (2.7 percent) and alanine transaminase (2.7 percent) levels, hypertension (2.7 percent), and hyperbilirubinemia (5.5 percent). No treatment-related deaths were reported.

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Editor's Recommendations
Most Read Articles
Dr Margaret Shi, 13 Jul 2020

An MRI-first diagnostic pathway, combined with risk-tailored screening, is shown to improve the benefit-to-harm profile and cost-effectiveness of screening for prostate cancer (PCa), according to results of a recent lifetable modelling study presented at AACR 2020 Virtual Meeting II.

Christina Lau, 14 Jul 2020

Flat-dose nivolumab, administered as a 30-minute infusion, is well tolerated and active in Asian patients with previously treated advanced non-small-cell lung cancer (NSCLC), according to results of the phase IIIb CheckMate 870 study.

Natalia Reoutova, 17 Jul 2020

At a median follow-up of 22.9 months, atezolizumab plus carboplatin and etoposide (CP/ET), given as a first-line treatment, continued to demonstrate an improvement in overall survival (OS) vs placebo plus CP/ET in patients with extensive-stage small-cell lung cancer (ES-SCLC), according to updated results of the IMpower133 trial presented at the American Association for cancer Research (AACR) 2020 Virtual Annual Meeting II.

12 Jun 2020
Drawing from experience as a key investigator in landmark clinical trials (including PALOMA, MONALEESA and MONARCH), and his clinical experience with CDK4/6 inhibitors, Dr Rafael Villanueva Vázquez shares his insights into the current evidence of using CDK4/6 inhibitors to treat HR+/HER2- ABC.