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Stephen Padilla, 23 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
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Regions of brain metastasis vary by breast cancer subtypes

25 Nov 2017
Radiologists interpret complex medical imaging to arrive at an accurate diagnosis

Different breast cancer subtypes appear to show different spatial distributions of brain metastasis (BM), with luminal type and human epidermal growth factor receptor 2 (HER2)-positive breast cancers showing BM dominance in the occipital lobe and cerebellum, suggests a recent study.

Brain magnetic resonance (MR) images of 100 breast cancer patients with confirmed BM were retrospectively analysed. Distribution patterns of BM were compared among and within groups, which were defined by biological subtype of the primary tumour.

In the study sample, 24 patients had triple-negative primary breast cancers (mean age at diagnosis 46.45±10.88 years), 48 were HER2-positive (mean age at diagnosis 49.5±11.45 years) and 28 had luminal breast cancer (mean age at diagnosis 46.75±9.73 years).

While the mean number of BM per patient did not differ among the subtypes (5.04±6.37, 4.71±6.58 and 5.35±6.69), both triple negative (23.5±23.36 months) and HER2-positive (19±29.54 months) cancers had significantly shorter time to BM than luminal breast cancers (42±45.51 months; p<0.01).

In intergroup analysis, researchers found that BM from triple-negative breast cancers was more likely to occur in the limbic region, parietal lobe and frontal lobe (corrected p<0.05) compared to the other cancer subtypes.

In contrast, HER2-positive breast cancers were less likely to have BM in the frontal lobe and subcortical regions, while BM from luminal type breast cancers were less likely to happen in the cerebellum, subcortical region and occipital lobe compared with the other cancer subtypes (corrected p<0.05).

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Most Read Articles
Stephen Padilla, 23 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
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15 Jun 2018
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