Most Read Articles
Pearl Toh, 6 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
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Red cell distribution width not linked to survival outcomes in colorectal cancer

04 Feb 2020

High red cell distribution width (RDW) does not seem to affect survival outcomes in patients with colorectal cancer (CRC), reports a recent study.

The retrospective study included 591 CRC patients who were categorized into two according to a median RDW cutoff value of 14.1 percent. RDW was measured from venous blood samples 2 weeks before the surgery. Outcomes included overall (OS) and cancer-related (CRS) survival.

The mean preoperative RDW value was 15.2±3.2 percent. This tended to be higher in participants who were older, had colon (vs rectal) cancer, had locally advanced malignancies and had higher Tumour, Node, Metastasis (TNM) stages. Nodal involvement, histology, tumour grading and systemic metastases were unrelated to RDW.

Five-year OS was significantly greater in those who were at most 67.5 years of age (79.7 percent vs 67.7 percent; p<0.001); the same was true of CRS (83.2 percent vs 75.2 percent; p=0.011). Systemic metastasis likewise affected both OS and CRS (p<0.001 for both), as did TNM staging (p<0.001 for both), nodal involvement (p<0.001 for both) and tumour grading (p<0.001 for both).

Analysis according to RDW showed no significant effect on 5-year OS between patients who were above vs below the median cutoff value (72.3 percent vs 74.7 percent). However, long-term survival favoured those with lower RDW values, with the divergence reaching statistical significance at 10 years (68.1 percent vs 54 percent; p=0.043). No such effect was reported for CRS.

Cox regression models confirmed that high RDW was unrelated to OS (hazard ratio [HR], 1.17, 95 percent confidence interval [CI], 0.86–1.6) or CRS (HR, 0.915, 95 percent CI, 0.64–1.32).

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Most Read Articles
Pearl Toh, 6 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.