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Stephen Padilla, 14 Mar 2019
Long-term use of systemic hormone therapy may increase the risk of Alzheimer’s disease in postmenopausal women, which is not associated with progestogen type or age at initiation of said therapy, according to a Finnish study. On the other hand, use of vaginal oestradiol does not appear to increase such risk.

Red, processed meat intake tied to shorter survival in colorectal cancer

15 Dec 2018

Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer (CRC) appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.

Researchers included 7,627 patients with stage I-IV CRC from 10 studies in the International Survival Analysis in Colorectal Cancer Consortium. They performed Cox proportional hazards regression analysis to evaluate the associations of intake of red and processed meat before diagnosis with overall and CRC-specific survival.

A total of 2,338 patients died over a median follow-up time of 5.1 years, among whom 1,576 had CRC-specific deaths.

In multivariable-adjusted analyses, higher intake level of red or processed meat showed no association with overall survival of patients with stage I–III CRC (Q4 vs Q1 red meat intake: hazard ratio [HR], 1.08; 95 percent CI, 0.93–1.26; Q4 vs Q1 processed meat intake: HR, 1.10; 0.93–1.32) or with CRC-specific survival (Q4 vs Q1 red meat intake: HR, 1.09; 0.89–1.33; Q4 vs Q1 processed meat intake: HR, 1.11; 0.87–1.42). Results were similar for patients with stage IV CRC.

On the other hand, the risk of death from any cause in patients with stage I–III CRC proved to be higher among those who reported an intake of processed meat above the study-specific medians vs those who reported eating at or less than the median (HR, 1.12; 1.01–1.25).

Researchers underscored a need for more studies evaluating dietary data from several time points before and after cancer diagnosis to confirm the present findings.

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Most Read Articles
Jairia Dela Cruz, 3 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.
5 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
6 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).
Stephen Padilla, 14 Mar 2019
Long-term use of systemic hormone therapy may increase the risk of Alzheimer’s disease in postmenopausal women, which is not associated with progestogen type or age at initiation of said therapy, according to a Finnish study. On the other hand, use of vaginal oestradiol does not appear to increase such risk.