Most Read Articles
6 days ago
Treatment with nebivolol yields more favourable changes in 24-hour, intradialytic and daytime systolic and diastolic blood pressure variability in patients with intradialytic hypertension, a study has found.
Stephen Padilla, 4 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
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Recombinant thrombomodulin safely improves acute exacerbation in idiopathic interstitial pneumonias

12 Jul 2019
Smoking is one cause of idiopathic pulmonary fibrosis, apart from hereditary factors and inhalation of certain types of dust.

Recombinant human soluble thrombomodulin (rhTM) is a safe and effective treatment for acute exacerbation (AE) in other idiopathic interstitial pneumonias (IIP), a recent study has shown.

AE-IIP patients treated with rhTM had a 90-day survival rate of 66.7 percent (26/39), while those who were not treated with rhTM had a survival rate of 47.5 percent (29/61). After adjusting for imbalances, a significant association was found between rhTM therapy and reduced mortality (adjusted hazard ratio, 0.453, 95 percent CI, 0.237–0.864; p=0.0163).

Adverse events occurred in 17.9 percent (7/39) of patients treated with rhTM and in 19.7 percent (12/61) of those who did not receive rhTM, which were comparable in both groups (p=1.0). In addition, the rhTM group reported two cases of bleeding events.

Future randomized controlled trials are warranted to confirm these findings.

This prospective, single-arm, open-label, multicentre cohort study retrospectively registered 61 patients with AE-IIP who were treated with conventional therapy between 2011 and 2013 (control group) and prospectively included 39 patients with AE-IIP who received conventional therapy and rhTM (380 U/kg/day for 6 days) between 2014 and 2016 (rhTM group).

The investigators conducted an adjusted mortality analysis for 90-day survival with weighted Cox proportional regression models using inverse probability of treatment weighting to reduce potential confounding in treatment comparisons. Weights were derived from propensity score estimated using a multivariable logistic regression analysis, including potential confounders.

“AE in idiopathic pulmonary fibrosis or other IIP is a poor prognostic event despite conventional therapy with corticosteroids and/or immunosuppressants,” the investigators said.

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Most Read Articles
6 days ago
Treatment with nebivolol yields more favourable changes in 24-hour, intradialytic and daytime systolic and diastolic blood pressure variability in patients with intradialytic hypertension, a study has found.
Stephen Padilla, 4 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
The known benefits of coffee drinking keep on growing as a new study suggests that coffee consumption can lower the risk of liver-related hospitalizations.