Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 6 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
13 Jul 2019
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
6 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.

Recombinant thrombomodulin safely improves acute exacerbation in idiopathic interstitial pneumonias

12 Jul 2019
Smoking is one cause of idiopathic pulmonary fibrosis, apart from hereditary factors and inhalation of certain types of dust.

Recombinant human soluble thrombomodulin (rhTM) is a safe and effective treatment for acute exacerbation (AE) in other idiopathic interstitial pneumonias (IIP), a recent study has shown.

AE-IIP patients treated with rhTM had a 90-day survival rate of 66.7 percent (26/39), while those who were not treated with rhTM had a survival rate of 47.5 percent (29/61). After adjusting for imbalances, a significant association was found between rhTM therapy and reduced mortality (adjusted hazard ratio, 0.453, 95 percent CI, 0.237–0.864; p=0.0163).

Adverse events occurred in 17.9 percent (7/39) of patients treated with rhTM and in 19.7 percent (12/61) of those who did not receive rhTM, which were comparable in both groups (p=1.0). In addition, the rhTM group reported two cases of bleeding events.

Future randomized controlled trials are warranted to confirm these findings.

This prospective, single-arm, open-label, multicentre cohort study retrospectively registered 61 patients with AE-IIP who were treated with conventional therapy between 2011 and 2013 (control group) and prospectively included 39 patients with AE-IIP who received conventional therapy and rhTM (380 U/kg/day for 6 days) between 2014 and 2016 (rhTM group).

The investigators conducted an adjusted mortality analysis for 90-day survival with weighted Cox proportional regression models using inverse probability of treatment weighting to reduce potential confounding in treatment comparisons. Weights were derived from propensity score estimated using a multivariable logistic regression analysis, including potential confounders.

“AE in idiopathic pulmonary fibrosis or other IIP is a poor prognostic event despite conventional therapy with corticosteroids and/or immunosuppressants,” the investigators said.

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Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 6 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
13 Jul 2019
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
6 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.