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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
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Readmissions up mortality risk in heart failure patients

19 Dec 2020

In heart failure (HF) patients, readmissions due to worsening condition is common and may be an indicator of worse clinical outcomes and mortality risk, a recent Japan study has found.

From the Japanese Diagnosis Procedure Combination Database, the researchers identified 331,259 HF patients (median age, 81 years; 52.9 percent male) who had been first hospitalized for HF between January 2010 and March 2018. Participants were then grouped according to the number of times they were admitted: once, twice, thrice, four times, and five or more times.

Respiratory support and the use of inotropics were more commonly recorded in patients who had been readmitted, and the need for either grew with increasing admissions. In-hospital deaths showed a similar pattern of interaction with hospital admissions, while discharge to home showed the opposite trend.

Multivariable logistic regression analysis confirmed these findings. Being hospitalized just twice significantly increased the likelihood of in-hospital mortality by more than 50 percent (odds ratio [OR], 1.57, 95 percent confidence interval [CI], 1.50–1.64; p<0.001).

This risk of death further increased with more hospitalizations. Those who had been admitted thrice were twice as likely to die (OR, 2.01, 95 percent CI, 1.89–2.14; p<0.001), while those who were hospitalized at least five times saw an almost threefold increase in in-hospital mortality risk (OR, 2.83, 95 percent CI, 2.59–3.08; p<0.001).

“To date, it has not been concluded whether each hospital admission due to HF could deteriorate clinical outcomes. Our comprehensive analysis of a large-scale nationwide database clearly demonstrated that the risk of in-hospital death increased in association with an increasing number of hospital admissions,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.