Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

Re-emergence of pertussis in the post-vaccination era: A Malaysian perspective

6 days ago
Q1. Could you please describe the current state of pertussis epidemiology,both local and globally?
Pertussis is a worldwide epidemic infectious disease, without breaks occurring every 2–5 years. In the prevaccine era, the incidence and case-fatality rates of pertussis were very high, especially among children aged younger than 5 years. The diphtheria-tetanus-pertussis combination vaccine (ie, DTP vaccine), which has been part of the World Health Organisation (WHO)’s Expanded Programme on Immunisation since 1974, has resulted in a dramatic decline in pertussis incidence and mortality. Without vaccination, the disease would have resulted in more than 1.3 million deaths globally in the year 2001.1

According to WHO, the global vaccination coverage of the DTP3 vaccine in 2013 was estimated at 84%2; in the same year, pertussis was reported to have caused as many as 63,000 deaths in children aged younger than 5 years worldwide.1 In 2018, WHO estimated that about 86% of infants (or 116.3 million infants) worldwide received DTP3, but approximately 19.4 million infants did not have access to routine immunisation services, including the DTP3 vaccine,during the same period.3

In Malaysia, the incidence of pertussis was less than 1/100,000 population prior to 2012, with no deaths in the preceding decade 4; however, the incidence of pertussis increased almost 22-fold from 41 cases in 2010 to 892 cases in 2018.5 According to the Ministry of Health (MOH), there were 22 deaths from pertussis in 2018 alone and 19 of the affected children had no prior history of vaccination.6

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Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.