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Re-emergence of pertussis in the post-vaccination era: A Malaysian perspective

06 Nov 2019
Q1. Could you please describe the current state of pertussis epidemiology,both local and globally?
Pertussis is a worldwide epidemic infectious disease, without breaks occurring every 2–5 years. In the prevaccine era, the incidence and case-fatality rates of pertussis were very high, especially among children aged younger than 5 years. The diphtheria-tetanus-pertussis combination vaccine (ie, DTP vaccine), which has been part of the World Health Organisation (WHO)’s Expanded Programme on Immunisation since 1974, has resulted in a dramatic decline in pertussis incidence and mortality. Without vaccination, the disease would have resulted in more than 1.3 million deaths globally in the year 2001.1

According to WHO, the global vaccination coverage of the DTP3 vaccine in 2013 was estimated at 84%2; in the same year, pertussis was reported to have caused as many as 63,000 deaths in children aged younger than 5 years worldwide.1 In 2018, WHO estimated that about 86% of infants (or 116.3 million infants) worldwide received DTP3, but approximately 19.4 million infants did not have access to routine immunisation services, including the DTP3 vaccine,during the same period.3

In Malaysia, the incidence of pertussis was less than 1/100,000 population prior to 2012, with no deaths in the preceding decade 4; however, the incidence of pertussis increased almost 22-fold from 41 cases in 2010 to 892 cases in 2018.5 According to the Ministry of Health (MOH), there were 22 deaths from pertussis in 2018 alone and 19 of the affected children had no prior history of vaccination.6

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.