Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Re-emergence of pertussis in the post-vaccination era: A Malaysian perspective

06 Nov 2019
Q1. Could you please describe the current state of pertussis epidemiology,both local and globally?
Pertussis is a worldwide epidemic infectious disease, without breaks occurring every 2–5 years. In the prevaccine era, the incidence and case-fatality rates of pertussis were very high, especially among children aged younger than 5 years. The diphtheria-tetanus-pertussis combination vaccine (ie, DTP vaccine), which has been part of the World Health Organisation (WHO)’s Expanded Programme on Immunisation since 1974, has resulted in a dramatic decline in pertussis incidence and mortality. Without vaccination, the disease would have resulted in more than 1.3 million deaths globally in the year 2001.1

According to WHO, the global vaccination coverage of the DTP3 vaccine in 2013 was estimated at 84%2; in the same year, pertussis was reported to have caused as many as 63,000 deaths in children aged younger than 5 years worldwide.1 In 2018, WHO estimated that about 86% of infants (or 116.3 million infants) worldwide received DTP3, but approximately 19.4 million infants did not have access to routine immunisation services, including the DTP3 vaccine,during the same period.3

In Malaysia, the incidence of pertussis was less than 1/100,000 population prior to 2012, with no deaths in the preceding decade 4; however, the incidence of pertussis increased almost 22-fold from 41 cases in 2010 to 892 cases in 2018.5 According to the Ministry of Health (MOH), there were 22 deaths from pertussis in 2018 alone and 19 of the affected children had no prior history of vaccination.6

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.