Most Read Articles
4 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Roshini Claire Anthony, 10 Jul 2019

Women who receive a single dose of amoxicillin and clavulanic acid within 6 hours of operative vaginal delivery could significantly reduce their postpartum infection risk, according to the UK-based ANODE* trial.

Pearl Toh, Yesterday
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
4 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.

Rapid lung function decline in post-HSCT BOS patients tied to poor survival outcome

09 May 2019

Lung function is significantly poorer while overall survival (OS) is worse among posthaematopoietic stem cell transplantation (post-HSCT) bronchiolitis obliterans syndrome (BOS) patients with initial rapid lung function decline within 3 months after BOS diagnosis compared to those with initial gradual decline in lung function after diagnosis, according to a study.

Ninety-five (6.5 percent) of 1,461 patients who underwent allogeneic HSCT between 1998 and 2015 were diagnosed with BOS. A matched cohort of HSCT recipients without BOS (n=159) was identified.

Those with a 25-percent decline in FEV1 within the first 3 months after BOS diagnosis were separated into a subgroup with initial rapid decline and another subgroup with initial gradual decline in lung function. Patients in the rapid decline group had lower subsequent lung function parameters and significantly worse OS compared to those in the gradual decline group (p=0.013).

“HSCT BOS patients with rapid initial decline in lung function warrant closer monitoring for the development of other post‐HSCT complications that could affect their survival,” the authors said.

This study compared BOS patients to those without BOS and matched them for age, gender, primary diagnoses, conditioning regimes and chronic graft versus host disease. The authors assessed lung function tests at baseline, at BOS diagnosis and every 3 months after HSCT.

Post-HSCT BOS presents with lung function decline, and the pattern of such a decline after BOS diagnosis could affect prognostications of BOS as a complication after HSCT, according to the authors.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Roshini Claire Anthony, 10 Jul 2019

Women who receive a single dose of amoxicillin and clavulanic acid within 6 hours of operative vaginal delivery could significantly reduce their postpartum infection risk, according to the UK-based ANODE* trial.

Pearl Toh, Yesterday
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
4 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.