Most Read Articles
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Pank Jit Sin, 21 May 2020
Two new studies have brought into question the widespread use of hydroxychloroquine in COVID-19 patients. One is French in origin while the other is Chinese.

Rapid decline in lung function tied to higher CVD risk

07 Sep 2018

A declining lung function, assessed by serial spirometry, may result in a higher incidence of subsequent cardiovascular disease (CVD), particularly incident heart failure (HF), suggests a recent study.

In the ARIC (Atherosclerosis Risk In Communities) study, 20,351 participants (mean age 54±6 years; 56 percent women; 81 percent white) free of CVD were included. Among these, rapid lung function decline was defined as the greatest quartile (n=2,585) of decline in either forced expiratory volume in 1 s (FEV1; >1.9-percent decline/year) or forced vital capacity (FVC; >2.1-percent decline/year) over 2.9±0.2 years.

The authors evaluated the relationship between rapid decline in FEV1 or FVC and subsequent incident HF, coronary heart disease (CHD), stroke or a composite of these using multivariable Cox regression adjusting for the baseline spirometry value, demographics, height, body mass index, heart rate, diabetes, hypertension, low-density lipoprotein, use of lipid-lowering medication, N-terminal fragment of prohormone for B-type natriuretic peptide and smoking.

HF occurred in 14 percent, CHD in 11 percent, stroke in 6 percent and the composite in 24 percent during 17±6 years of follow-up.

An association was observed between a rapid decline in FEV1 and in FVC and a heightened risk of incident HF (hazard ratio [HR], 1.17; 95 percent CI, 1.04–1.33; p=0.010 and HR, 1.27; 1.12–1.44; p<0.001; respectively), with a rapid decline in FEV1 most prognostic in the first year of follow-up (HR, 4.22; 1.34–13.26; p=0.01). Additionally, rapid decline in FEV1 correlated with incident stroke (HR, 1.25; 1.04–1.50; p=0.015).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Pank Jit Sin, 21 May 2020
Two new studies have brought into question the widespread use of hydroxychloroquine in COVID-19 patients. One is French in origin while the other is Chinese.