Most Read Articles
30 May 2019
Women with chronic obstructive pulmonary disease (COPD) are at higher risk of exacerbations despite evidence for milder disease at diagnosis compared with men, a study reports.
Roshini Claire Anthony, 11 Jun 2019

The reduced mortality/morbidity benefit previously demonstrated with selexipag in patients with pulmonary arterial hypertension (PAH) may be more pronounced when treatment is initiated soon after diagnosis, according to results of a post hoc analysis of the GRIPHON* study presented as a poster at ATS 2019.

Tristan Manalac, 11 Sep 2018
The immediate reduction of cigarette nicotine content results in greater improvements in levels of smoke exposure biomarkers than gradual reduction, though withdrawal symptoms are stronger, according to a recent study.

Rapid decline in lung function tied to higher CVD risk

07 Sep 2018

A declining lung function, assessed by serial spirometry, may result in a higher incidence of subsequent cardiovascular disease (CVD), particularly incident heart failure (HF), suggests a recent study.

In the ARIC (Atherosclerosis Risk In Communities) study, 20,351 participants (mean age 54±6 years; 56 percent women; 81 percent white) free of CVD were included. Among these, rapid lung function decline was defined as the greatest quartile (n=2,585) of decline in either forced expiratory volume in 1 s (FEV1; >1.9-percent decline/year) or forced vital capacity (FVC; >2.1-percent decline/year) over 2.9±0.2 years.

The authors evaluated the relationship between rapid decline in FEV1 or FVC and subsequent incident HF, coronary heart disease (CHD), stroke or a composite of these using multivariable Cox regression adjusting for the baseline spirometry value, demographics, height, body mass index, heart rate, diabetes, hypertension, low-density lipoprotein, use of lipid-lowering medication, N-terminal fragment of prohormone for B-type natriuretic peptide and smoking.

HF occurred in 14 percent, CHD in 11 percent, stroke in 6 percent and the composite in 24 percent during 17±6 years of follow-up.

An association was observed between a rapid decline in FEV1 and in FVC and a heightened risk of incident HF (hazard ratio [HR], 1.17; 95 percent CI, 1.04–1.33; p=0.010 and HR, 1.27; 1.12–1.44; p<0.001; respectively), with a rapid decline in FEV1 most prognostic in the first year of follow-up (HR, 4.22; 1.34–13.26; p=0.01). Additionally, rapid decline in FEV1 correlated with incident stroke (HR, 1.25; 1.04–1.50; p=0.015).

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Most Read Articles
30 May 2019
Women with chronic obstructive pulmonary disease (COPD) are at higher risk of exacerbations despite evidence for milder disease at diagnosis compared with men, a study reports.
Roshini Claire Anthony, 11 Jun 2019

The reduced mortality/morbidity benefit previously demonstrated with selexipag in patients with pulmonary arterial hypertension (PAH) may be more pronounced when treatment is initiated soon after diagnosis, according to results of a post hoc analysis of the GRIPHON* study presented as a poster at ATS 2019.

Tristan Manalac, 11 Sep 2018
The immediate reduction of cigarette nicotine content results in greater improvements in levels of smoke exposure biomarkers than gradual reduction, though withdrawal symptoms are stronger, according to a recent study.