Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
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Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
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Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.

Rapid decline in lung function tied to higher CVD risk

07 Sep 2018

A declining lung function, assessed by serial spirometry, may result in a higher incidence of subsequent cardiovascular disease (CVD), particularly incident heart failure (HF), suggests a recent study.

In the ARIC (Atherosclerosis Risk In Communities) study, 20,351 participants (mean age 54±6 years; 56 percent women; 81 percent white) free of CVD were included. Among these, rapid lung function decline was defined as the greatest quartile (n=2,585) of decline in either forced expiratory volume in 1 s (FEV1; >1.9-percent decline/year) or forced vital capacity (FVC; >2.1-percent decline/year) over 2.9±0.2 years.

The authors evaluated the relationship between rapid decline in FEV1 or FVC and subsequent incident HF, coronary heart disease (CHD), stroke or a composite of these using multivariable Cox regression adjusting for the baseline spirometry value, demographics, height, body mass index, heart rate, diabetes, hypertension, low-density lipoprotein, use of lipid-lowering medication, N-terminal fragment of prohormone for B-type natriuretic peptide and smoking.

HF occurred in 14 percent, CHD in 11 percent, stroke in 6 percent and the composite in 24 percent during 17±6 years of follow-up.

An association was observed between a rapid decline in FEV1 and in FVC and a heightened risk of incident HF (hazard ratio [HR], 1.17; 95 percent CI, 1.04–1.33; p=0.010 and HR, 1.27; 1.12–1.44; p<0.001; respectively), with a rapid decline in FEV1 most prognostic in the first year of follow-up (HR, 4.22; 1.34–13.26; p=0.01). Additionally, rapid decline in FEV1 correlated with incident stroke (HR, 1.25; 1.04–1.50; p=0.015).

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Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
23 hours ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
5 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.