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26 Apr 2016
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Rapid decline in lung function tied to higher CVD risk

07 Sep 2018

A declining lung function, assessed by serial spirometry, may result in a higher incidence of subsequent cardiovascular disease (CVD), particularly incident heart failure (HF), suggests a recent study.

In the ARIC (Atherosclerosis Risk In Communities) study, 20,351 participants (mean age 54±6 years; 56 percent women; 81 percent white) free of CVD were included. Among these, rapid lung function decline was defined as the greatest quartile (n=2,585) of decline in either forced expiratory volume in 1 s (FEV1; >1.9-percent decline/year) or forced vital capacity (FVC; >2.1-percent decline/year) over 2.9±0.2 years.

The authors evaluated the relationship between rapid decline in FEV1 or FVC and subsequent incident HF, coronary heart disease (CHD), stroke or a composite of these using multivariable Cox regression adjusting for the baseline spirometry value, demographics, height, body mass index, heart rate, diabetes, hypertension, low-density lipoprotein, use of lipid-lowering medication, N-terminal fragment of prohormone for B-type natriuretic peptide and smoking.

HF occurred in 14 percent, CHD in 11 percent, stroke in 6 percent and the composite in 24 percent during 17±6 years of follow-up.

An association was observed between a rapid decline in FEV1 and in FVC and a heightened risk of incident HF (hazard ratio [HR], 1.17; 95 percent CI, 1.04–1.33; p=0.010 and HR, 1.27; 1.12–1.44; p<0.001; respectively), with a rapid decline in FEV1 most prognostic in the first year of follow-up (HR, 4.22; 1.34–13.26; p=0.01). Additionally, rapid decline in FEV1 correlated with incident stroke (HR, 1.25; 1.04–1.50; p=0.015).

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Most Read Articles
26 Apr 2016
Varenicline increases the rate of smoking cessation in individuals who smoke less than 10 cigarettes/day (cpd) based on a randomised, placebo- controlled clinical trial.
19 Jul 2016
New therapies that specifically target inflammatory pathways or aberrant physiology in severe asthma offer substantial opportunities for effective treatment. Some of these therapies are available under specialist referral, and others are available in the context of clinical trials.
Audrey Abella, 13 Dec 2016
Even a small number of cigarettes per day (CPD) used in the long term increases mortality risk, according to a  US study, highlighting the importance of smoking cessation.