Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Radical prostatectomy with radiotherapy cuts mortality risk in prostate cancer

28 Sep 2018
Prostate cancer is a silent killer. Many may not be aware of the illness until it is too late.

Radical prostatectomy (RP) with radiotherapy (XRT) reduces the risk of disease-specific death in patients with locally (LAPCa) and regionally advanced (RAPCa) prostate cancer, a recent study shows.

Researchers enrolled 13,856 RAPCa or LAPCa patients, about half of whom were treated with a single modality alone. Most of these patients received RP alone (20.8 percent; n=2,884), followed by XRT (18.3 percent; n=2,541) and androgen deprivation therapy (APT; 11.2 percent; n=1,545) alone.

In comparison, almost 30 percent of the men received multimodal treatment: RP plus XRT (6.1 percent; n=848) and XRT plus ADT (23.6 percent; n=3,272). The remaining 20 percent (n=2,766) did not receive any treatment within 6 months of diagnosis.

After a median follow-up period of 14.6 years, researchers reported 2,189 deaths. Propensity score-adjusted Cox proportional hazards models showed that patients who underwent RP with XRT were less likely to die, both from any and prostate cancer-related causes.

For instance, disease-specific mortalities from T3aN0M0 (adjusted hazard ratio [HR], 4.22; 95 percent CI, 2.83–6.28), T4N0M0 (adjusted HR, 2.31; 1.05–5.12) and T3bN0M0 (adjusted HR, 1.84; 1.34–2.53) malignancies were significantly less likely.

Kaplan-Meier estimates further confirmed the survival benefits associated with RP plus XRT. In men with T3a/bN0-NXM0 disease, the corresponding adjusted 10-year disease-specific survival rates for RP with XRT and ADT with XRT were 88.9 percent and 74.2 percent. The resulting survival difference achieved statistical significance in favour of RP with XRT (difference, 14.7 percent; 11.4–17.2).

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.