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Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

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Radiation to heart weakens cardiorespiratory fitness in lung, breast cancer survivors

22 Mar 2020
Stereotactic body radiation therapy or SBRT which was previously used for brain and lung cancers, could revolutionise prostate cancer treatments

Radiation dose appears to impair cardiorespiratory fitness in lung or breast cancer survivors, reports a new study.

Researchers enrolled 25 cancer survivors (median age, 63 years; 60 percent female) who had been treated with thoracic radiotherapy with incidental significant cardiac involvement. Cardiorespiratory fitness was measured as peak oxygen consumption; doppler echocardiography was also performed to derive the diastolic functional reserve index (DFRI).

The median mean cardiac radiation dose (MCRD) delivered in the overall cohort was 5.4 Gy, though this was significantly higher in those with lung cancer (10.3 vs 3.7 Gy; p<0.001). The total prescribed dose in the overall cohort was 60.0 Gy and was comparable between lung and breast cancer patients (60.2 vs 60.2 Gy, respectively; p=0.98).

The relative peak oxygen consumption in the overall cohort was 16.8 mL·kg-1min-1, while median DFRI was 27.3. Multivariate linear regression modelling found that MCRD was significantly and inversely correlated with peak oxygen consumption (R, –0.445; p=0.02).

Moreover, researchers found that DFRI (β, 0.0813; p<0.01) and levels of N-terminal pro-brain natriuretic peptide (β, –0.414; p=0.04) were likewise significant predictors of peak oxygen consumption.

“[I]mpairment in cardiorespiratory fitness shows a dose-dependent relationship with the radiation dose to the heart, and is primarily related to impaired diastolic reserve,” said researchers. “This study warrants further investigation into radiation-induced exercise intolerance and the efficacy of interventions to improve cardiorespiratory fitness in this population.”

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Most Read Articles
Stephen Padilla, 5 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Roshini Claire Anthony, 08 May 2020

At present, there are no definitive treatments for COVID-19. More than 300 clinical trials are ongoing in the search for a cure. Some of the treatments being tested were previously used, with varying levels of efficacy, in the treatment of severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS).

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Pank Jit Sin, 21 May 2020
Two new studies have brought into question the widespread use of hydroxychloroquine in COVID-19 patients. One is French in origin while the other is Chinese.