Race, depression tied to more bother from lower urinary tract symptoms
Urinary symptom severity at baseline, race, depression and psychological stress appear to exacerbate the bother of lower urinary tract symptoms (LUTS) in men and women treated at tertiary care facilities, a recent study has shown.
LUTS bother worsened in 121 (16 percent) of 756 participants during the study period. Adjusting for other variables, LUTS bother worsened among men who were nonwhite (odds ratio [OR], 1.79, 95 percent CI, 0.94–3.40) or who had diabetes (OR, 1.68, 0.86–3.27) and among women with diabetes (OR, 1.77, 0.85–3.67), prior to treatment of LUTS (OR, 2.58, 1.22–5.46) or with a higher depression level (OR, .129, 1.10–1.52).
The following baseline factors were associated with more severe bother at 12 months in men: more severe bother, nonwhite race, worse urinary frequency and incontinence, and higher levels of stress (p<0.05). In women, more severe bother at 12 months correlated with worse physical function, urinary urgency and frequency, and more severe bother at baseline.
“These findings may inform the clinical care of patients with bothersome LUTS and direct providers to better prognosticate for patients with challenging LUTS cases,” the authors said.
This 1-year prospective, observational cohort study analysed data on patients with LUTS who were seeking treatment at six tertiary care centres in the US. Participants answered the AUA-SI (American Urological Association Symptom Index) global urinary bother question at study entry and at month 12. Factors linked to worsening bother and bother at 12 months were identified using multilevel logistic and linear regression, respectively.