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RA-induced sleep apnoea tied to CVD, cerebrovascular disease

12 Jan 2018

It appears that patients with rheumatoid arthritis (RA) are at an increased risk of obstructive sleep apnoea (OSA) secondary to both traditional and RA-related risk factors, a recent study has found.

Individuals with RA vs comparators had an elevated risk for OSA, but the association did not reach statistical significance (hazard ratio [HR], 1.32; 95 percent CI, 0.98‒1.77; p=0.07). OSA diagnosis was probable among RA patients if they had traditional risk factors for OSA, such as male sex, hypertension, diabetes, dyslipidaemia, current smoking status and increased body mass index.

Furthermore, RA patients with large joint swelling and/or joint surgery were more likely to have a diagnosis of OSA. Those with RA and decreased renal function also had an increased risk of OSA.

The increased risk of overall cardiovascular disease (CVD) was comparable between individuals with RA who have OSA and those in the comparator cohort (p=0.86 for interaction). In patients with RA, an association existed between OSA diagnosis and increased risk of both CVD (HR, 1.9; 1.08‒3.27) and cerebrovascular disease (HR, 2.4; 1.14‒5.26).

“Diagnosis with OSA predicts future CVD in RA and may provide an opportunity for CVD intervention,” the investigators said.

This study aimed to describe the incidence of OSA in patients with RA and determine whether OSA diagnosis was a risk factor for future CVD and noncardiac vascular events. The investigators extracted medical data pertaining to RA, OSA, CVD and vascular diagnoses from a comprehensive medical record system for a geographically defined population of 813 patients previously diagnosed with RA and 813 age- and sex-matched comparator individuals.

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Most Read Articles
Stephen Padilla, 3 days ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 6 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
Jairia Dela Cruz, 3 days ago
A treatment regimen combining daratumumab plus bortezomib, melphalan and prednisone markedly extends progression-free survival in patients with multiple myeloma, inducing deep responses and demonstrating acceptable tolerability regardless of baseline renal function, according to the results of the phase III ALCYONE study.
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