Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

R-EPOCH, R-HCVAD superior to R-CHOP for primary mediastinal large B-cell lymphoma

12 Jun 2020

The R-EPOCH* and R-HCVAD** regimens yield better outcomes in patients with primary mediastinal large B-cell lymphoma (PMBCL) than R-CHOP***, a recent study has found.

The retrospective analysis included 166 PMBCL patients (median age, 33 years; 72 men) who were followed for a median of 58 months. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 79 percent and 70 percent, respectively. Those with more advanced disease and those who were older had worse survival outlook.

Most of the patients (n=89) were treated with R-CHOP as a first-line regimen, while 55 received four to seven cycles of R-EPOCH and 19 were given three to eight cycles of R-HCVAD. Objective response rates were higher in the two latter treatments (98 percent and 100 percent vs 91 percent, respectively), though the difference was not significant.

However, over the corresponding median follow-up lengths of 56.8, 126.2 and 54.8 months, R-EPOCH and R-HCVAD led to better OS and PFS rates than R-CHOP, respectively. Radiation therapy, administered in 85 patients, did not yield significant clinical benefit.

Thirty-one patients received stem cell transplants (25 autologous, six allogeneic), which seemed to improve OS in patients with relapsed or refractory PMBCL, especially in those who were initially partially responsive to treatment.

“In this large multicentric cohort analysis, we demonstrated that R-HCVAD and R-EPOCH provide superior clinical outcomes in PMBCL than R-CHOP as front-line immunochemotherapy that should be integrated into the clinical practice guidelines,” the researchers said.

“For relapsed or refractory PMBCL, autologous or allogenic stem cell transplantation after high-dose chemotherapy as the standard of care is an effective therapeutic strategy for PMBCL,” they added.

*etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab

**rituximab, cyclophosphamide, mesna, doxorubicin, vincristine, dexamethasone, methotrexate, and cytarabine

***cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab

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Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.