Most Read Articles
Pearl Toh, 2 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
5 days ago
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.

Quantitative elastography on par with fine-needle aspiration in evaluating pancreatic solid masses

03 Aug 2019

It appears that quantitative elastography (QE) is as good as fine-needle aspiration (FNA) in the assessment of pancreatic solid masses (PSMs), but the former can be used as a potential alternative of the latter in cases where the new strain ratio (SR) cutoff-based classifications are applied, suggests a study.

A total of 134 patients (mean age, 53 years; 53 percent women) were included, with a median tumour size of 30 (10–78) mm. Of these, 69.4 percent were malignant and 30.6 percent were benign tumours (median SR, 19.5 vs 7.5; p=0.000), and 87 percent were pancreatic adenocarcinoma.

In both PSM types, parameters were comparable between QE with SR cutoff ≥10 and FNA (for malignant tumour: sensitivity, 94 percent in both; specificity, 85 percent vs 87 percent; positive predictive value, 93 percent vs 94 percent; negative predictive value, 87 percent in both; and accuracy, 92 percent; for benign tumour: sensitivity, 85 percent vs 87 percent; specificity, 94 percent in both; positive predictive value, 87 percent in both; negative predictive value, 93 percent vs 94 percent; accuracy, 92 percent).

The area under the curve was 0.96 (95 percent CI, 0.940–0.995; p<0.000). New classifications based on positive likelihood ratio were created: A ≤8.7 (benign tumour), B >8.7 to <15.5 (indeterminate), and C ≥15.5 (malignant tumour).

This prospective study was conducted between January and December 2016 and included patients with suspected PSM. Those with advanced disease and cystic components were excluded. Both QE and FNA were performed, and histologic information was obtained for the final diagnoses. The authors then calculated diagnostic tests and receiver-operating characteristic curve.

“[E]ndoscopic ultrasound with FNA enables tissue acquisition but has high false-negative rates, [while] QE predicts diagnosis on the basis of the SR,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 2 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
5 days ago
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.