Most Read Articles
2 days ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 6 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
4 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
3 days ago
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.

Quality of life, mental health poorer in patients with rare cancers

11 Oct 2018
Cancer is hard enough as it is – unnecessarily increasing the treatment does not help patients, doctors or the practice of healthcare in general.

Patients with rare cancers have worse psychosocial and quality of life outcomes compared with the general population of cancer patients, a recent study has shown.

Using the Distress Thermometer (DT), Hospital Anxiety and Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General version, researchers assessed the mental health status and quality of life in 137 patients (mean age 50 years; 52.6 percent male) diagnosed with rare cancers. Chi-square tests were used to compare the rare vs general cancer populations.

In the study population, the most frequent form of rare cancer was seminoma of the testis, reported in 10.3 percent (n=14) of the participants. This was followed by endometroid adenocarcinoma (7.3 percent) and gastrointestinal stromal sarcoma (5.8 percent). Majority of the participants had received chemotherapy (73.7 percent) and surgery (76.6 percent).

According to the DT scale, almost half (49.6 percent) of the participants had moderate-to-severe distress, which was significantly higher than that in a US-based pan-cancer population (p=0.006). Physical (92.7 percent) and emotional (73.7 percent) problems were the principal drivers of distress.

Results of the HADS showed that the prevalence rates of anxiety and depressive symptoms were 19.7 percent and 15.3 percent, respectively, both of which were nonsignficantly lower than those in the pan-cancer cohort (24.0 percent and 15.3 percent, respectively).

Multivariate analysis identified various risk factors. Younger age was associated with significantly higher levels of distress (p=0.02), as were female sex (p<0.01) and undergoing evaluation during the active treatment phase (p=0.03). Female sex (p=0.0002) and being younger (p=0.04) were associated with greater anxiety.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Psychiatry - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 6 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
4 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
3 days ago
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.