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QTc prolongation uncommon in critically ill patients using quetiapine

15 Jun 2018

Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.

“Patients receiving concomitant medications known to prolong the QTc interval may be at an increased risk,” the authors said.

A total of 103 patients were enrolled in the analysis during the study period. Fourteen (13.6 percent) patients had QTc interval prolongation >60 ms. The median change in QTc interval was 20 ms.

No incidence of Torsades de Pointes (TdP), a form of polymorphic ventricular tachycardia in patients with a long QT interval, was reported. Multivariable analysis revealed that administration of a concomitant medication known to prolong the QTc interval was the only variable correlated with higher incidence of QTc prolongation (p=0.046).

This single-centre, prospective cohort analysis involved intensive care unit (ICU) patients receiving quetiapine between October 2015 and February 2016 to describe the impact of the study drug on QTc interval prolongation in critically ill patients.

The primary endpoint was the incidence of QTc prolongation >60 ms above baseline during therapy. Minor endpoints were median change in QTc interval and incidence of TdP. Variables associated with greater risk of QTc prolongation were determined by means of univariate and multivariable analyses.

“Quetiapine, an atypical antipsychotic used in the ICU to manage delirium, has a possible adverse effect of QTc interval prolongation,” the authors said.

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Most Read Articles
10 Feb 2019
Living a sedentary lifestyle may increase the risk of cardiovascular diseases (CVD) even in people with healthy body mass index (BMI), reports a new study.
14 Jun 2017
The use of spot urine appears to be unhelpful in estimating 24-hour urinary sodium excretion at the individual level due to its poor performance with regard to misclassification, according to a recent study.
5 days ago
Physician-guided cessation of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is safe in patients presenting with acute coronary syndrome, a recent study has shown.
22 Mar 2017
Exosomal microRNAs (miRNAs) in the serum are potential diagnostic biomarkers for Kawasaki disease (KD), a new study shows.