Most Read Articles
02 Jul 2018
The use of beta-blockers in patients with heart failure with preserved ejection fraction (HFpEF), especially in those without histories of myocardial infarction, appears to increase the risk of adverse cardiovascular events, according to a recent study.
Stephen Padilla, 6 days ago
Compared with warfarin, apixaban appears to be the safest drug among direct oral anticoagulants (DOACs), with decreased risks of major, intracranial and gastrointestinal bleeding, suggests a study. However, low-dose apixaban and rivaroxaban are associated with increased risks of all-cause mortality compared with warfarin.
24 Jun 2018
Sleep problems and depressive symptoms, and a combination of both, are differentially associated with the future incidence of physical illness, according to a study.
05 Jul 2018
Different measures of fitness and physical activity appear to be inversely associated with the risk of developing cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases, according to a study.

QTc prolongation uncommon in critically ill patients using quetiapine

15 Jun 2018

Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.

“Patients receiving concomitant medications known to prolong the QTc interval may be at an increased risk,” the authors said.

A total of 103 patients were enrolled in the analysis during the study period. Fourteen (13.6 percent) patients had QTc interval prolongation >60 ms. The median change in QTc interval was 20 ms.

No incidence of Torsades de Pointes (TdP), a form of polymorphic ventricular tachycardia in patients with a long QT interval, was reported. Multivariable analysis revealed that administration of a concomitant medication known to prolong the QTc interval was the only variable correlated with higher incidence of QTc prolongation (p=0.046).

This single-centre, prospective cohort analysis involved intensive care unit (ICU) patients receiving quetiapine between October 2015 and February 2016 to describe the impact of the study drug on QTc interval prolongation in critically ill patients.

The primary endpoint was the incidence of QTc prolongation >60 ms above baseline during therapy. Minor endpoints were median change in QTc interval and incidence of TdP. Variables associated with greater risk of QTc prolongation were determined by means of univariate and multivariable analyses.

“Quetiapine, an atypical antipsychotic used in the ICU to manage delirium, has a possible adverse effect of QTc interval prolongation,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
02 Jul 2018
The use of beta-blockers in patients with heart failure with preserved ejection fraction (HFpEF), especially in those without histories of myocardial infarction, appears to increase the risk of adverse cardiovascular events, according to a recent study.
Stephen Padilla, 6 days ago
Compared with warfarin, apixaban appears to be the safest drug among direct oral anticoagulants (DOACs), with decreased risks of major, intracranial and gastrointestinal bleeding, suggests a study. However, low-dose apixaban and rivaroxaban are associated with increased risks of all-cause mortality compared with warfarin.
24 Jun 2018
Sleep problems and depressive symptoms, and a combination of both, are differentially associated with the future incidence of physical illness, according to a study.
05 Jul 2018
Different measures of fitness and physical activity appear to be inversely associated with the risk of developing cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases, according to a study.