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Pulse pressure linked to long-term stroke outcomes among older patients

21 Aug 2017

There appears to be a significant association between pulse pressure (PP) and long-term stroke outcomes, and this relationship is evident among patients aged older than 60 years, a study has found.

Researchers looked at 4,195 patients (mean age 61.2 years; 68.4 percent male) with first-ever ischaemic stroke within 3 months of enrolment from The Standard Medical Management in Secondary Prevention of Ischemic Stroke in China (SMART) II study. The patients were stratified by age (<60 and ≥60 years) and had their baseline blood pressure (BP) measured. Study endpoints included the combined endpoints of recurrent vascular events and all-cause mortality, and recurrent stroke.

In the <60 years age group, BP components (systolic [S]BP, diastolic [D]BP, mean arterial pressure [MAP] and PP) had no significant association with long-term stroke outcomes. In the ≥60 years age group, PP was significantly related with the combined endpoints (hazards ratio [HR], 1.35; 95 percent CI, 1.18 to 1.54) and recurrent stroke (HR, 1.46; 1.24 to 1.72).

When dual BP components of SBP and PP, DBP and PP, or MAP and PP were analysed, SBP, DBP or MAP did not provide incremental value for predicting long-term stroke outcomes.

The present data indicate that PP within 3 months after ischaemic stroke is associated with 2-year outcomes of the combined endpoints and recurrent stroke among patients aged older than 60 years. Researchers noted that for every 1-SD increase in PP, there was a 35-percent increase in the risk of recurrent vascular events and all-cause mortality and a 46-percent increase in the risk of recurrent stroke.

“Higher PP, considered as an indicator or consequence of aortic stiffening, might [worsen] the long-term prognosis under stroke conditions,” researchers said.

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Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
13 Jun 2017
Both haemorrhagic and ischaemic stroke patients benefit similarly from a conventional therapy combined with robotic-assisted gait training (RAGT) intervention regimen, a new study shows.
30 Jun 2016
Perindopril can protect patients with paroxysmal atrial fibrillation (AF) from recurrence after radiofrequency catheter ablation, as stated in a study.
5 days ago
Enriching salt with both potassium and magnesium in the long term may provide additional benefits for stroke patient recovery from neurologic deficits, suggests a recent study involving Taiwanese patients.