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Pulse pressure linked to long-term stroke outcomes among older patients

21 Aug 2017

There appears to be a significant association between pulse pressure (PP) and long-term stroke outcomes, and this relationship is evident among patients aged older than 60 years, a study has found.

Researchers looked at 4,195 patients (mean age 61.2 years; 68.4 percent male) with first-ever ischaemic stroke within 3 months of enrolment from The Standard Medical Management in Secondary Prevention of Ischemic Stroke in China (SMART) II study. The patients were stratified by age (<60 and ≥60 years) and had their baseline blood pressure (BP) measured. Study endpoints included the combined endpoints of recurrent vascular events and all-cause mortality, and recurrent stroke.

In the <60 years age group, BP components (systolic [S]BP, diastolic [D]BP, mean arterial pressure [MAP] and PP) had no significant association with long-term stroke outcomes. In the ≥60 years age group, PP was significantly related with the combined endpoints (hazards ratio [HR], 1.35; 95 percent CI, 1.18 to 1.54) and recurrent stroke (HR, 1.46; 1.24 to 1.72).

When dual BP components of SBP and PP, DBP and PP, or MAP and PP were analysed, SBP, DBP or MAP did not provide incremental value for predicting long-term stroke outcomes.

The present data indicate that PP within 3 months after ischaemic stroke is associated with 2-year outcomes of the combined endpoints and recurrent stroke among patients aged older than 60 years. Researchers noted that for every 1-SD increase in PP, there was a 35-percent increase in the risk of recurrent vascular events and all-cause mortality and a 46-percent increase in the risk of recurrent stroke.

“Higher PP, considered as an indicator or consequence of aortic stiffening, might [worsen] the long-term prognosis under stroke conditions,” researchers said.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 08 Jun 2018

Early treatment of superficial venous reflux (varicose veins) with endovenous ablation and compression therapy shortened healing time of venous leg ulcers compared with compression therapy either alone or in addition to delayed ablation, according to the EVRA* trial.