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Tristan Manalac, 09 Sep 2018
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Pulse pressure linked to long-term stroke outcomes among older patients

21 Aug 2017

There appears to be a significant association between pulse pressure (PP) and long-term stroke outcomes, and this relationship is evident among patients aged older than 60 years, a study has found.

Researchers looked at 4,195 patients (mean age 61.2 years; 68.4 percent male) with first-ever ischaemic stroke within 3 months of enrolment from The Standard Medical Management in Secondary Prevention of Ischemic Stroke in China (SMART) II study. The patients were stratified by age (<60 and ≥60 years) and had their baseline blood pressure (BP) measured. Study endpoints included the combined endpoints of recurrent vascular events and all-cause mortality, and recurrent stroke.

In the <60 years age group, BP components (systolic [S]BP, diastolic [D]BP, mean arterial pressure [MAP] and PP) had no significant association with long-term stroke outcomes. In the ≥60 years age group, PP was significantly related with the combined endpoints (hazards ratio [HR], 1.35; 95 percent CI, 1.18 to 1.54) and recurrent stroke (HR, 1.46; 1.24 to 1.72).

When dual BP components of SBP and PP, DBP and PP, or MAP and PP were analysed, SBP, DBP or MAP did not provide incremental value for predicting long-term stroke outcomes.

The present data indicate that PP within 3 months after ischaemic stroke is associated with 2-year outcomes of the combined endpoints and recurrent stroke among patients aged older than 60 years. Researchers noted that for every 1-SD increase in PP, there was a 35-percent increase in the risk of recurrent vascular events and all-cause mortality and a 46-percent increase in the risk of recurrent stroke.

“Higher PP, considered as an indicator or consequence of aortic stiffening, might [worsen] the long-term prognosis under stroke conditions,” researchers said.

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Most Read Articles
Tristan Manalac, 09 Sep 2018
Structured and remote patient management interventions are effective in reducing all-cause mortality and the number of days lost due to unplanned hospitalizations in heart failure patients, according to a recent study.
Radha Chitale, 08 Apr 2016
A trial assessing the implantable CardioFit® device designed to stimulate the parasympathetic nervous system in heart failure patients failed to meet its primary endpoints – reducing the rate of hospitalization due to heart failure or death by any cause.
27 Aug 2018
Obese men appear to have better ST-elevation myocardial infarction (STEMI) prognoses than their normal weight counterparts, regardless of metabolic syndrome status, a recent study has shown.
Stephen Padilla, 04 Sep 2018
The prevalence of individuals with hypertension is expected to rise significantly with the implementation of the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) high blood pressure guidelines, according to a study.