Most Read Articles
Pearl Toh, 4 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 20 Oct 2020
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Pulmonary hypertension ups mortality risk even after repair of cardiac defect

12 May 2020

Pulmonary hypertension (PH) occurs rarely after correction of cardiac defects, but is nevertheless a significant mortality risk factor, a new study reports.

The retrospective study included 825 patients (median age, 23 years) with closed, isolated simple cardiac defects, such as atrial septal defect, ventricular septal defect and persistent atrial ducts. The primary study outcome was the risk of PH. Participants with genetic defects were excluded from the analysis.

Over a median follow-up of 15.9 years from defect closure, 25 participants developed PH, resulting in an incidence rate of 3.0 percent. These patients tended to be older and were more likely to have undergone defect closure later in life.

Age emerged as an important mediating factor. The prevalence of PH was 0.7 percent in participants <20 years of age. This shot up to 8.8 percent and 11.9 percent by the fifth and sixth decades of life, respectively. This was confirmed by logistic regression analysis, which showed that age at follow-up was a significant risk factor (odds ratio per additional year, 1.07, 95 percent confidence interval [CI], 1.02–1.11; p=0.003).

Fourteen patients died over the course of the study and the mortality rate was higher in the PH group (20 percent vs 1 percent). Age- and gender-adjusted Cox analysis verified the impact of PH on death risk (hazard ratio per year, 1.015, 95 percent CI, 1.01–1.072; p=0.003).

“Physicians should be aware of the increased risk of PH and its association with heart failure symptoms and increased mortality in this setting. A low threshold for specialized workup is recommended especially in the elderly to ascertain the diagnosis of PH, which has important prognostic and clinical implications,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 4 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 20 Oct 2020
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.