Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

PTH predicts mortality in coronary angiography patients with T2DM

02 Oct 2020

Serum parathyroid hormone (PTH) shows a significant and robust all-cause mortality in coronary angiography patients with type 2 diabetes mellitus (T2DM) compared with those without, a recent study has shown.

The investigators sought to examine the influence of T2DM on the power of PTH to predict mortality risk. They determined serum PTH levels in 904 consecutive Caucasian patients referred to coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD), including 235 patients with T2DM. Death was prospectively recorded over a mean follow-up period of 6.3 years.

No significant difference was seen in PTH at baseline between patients with and without T2DM (p=0.307). In Cox regression analysis, serum PTH level was found to be a strong predictor of all-cause mortality in patients with T2DM (hazard ratio [HR], 2.35, 95 percent confidence interval [CI], 1.37–4.03; p=0.002), but not in those without (HR, 1.04, 95 percent CI, 0.81–1.32; p=0.766).

A significant association was observed between PTH and T2DM (p=0.006), indicating a significant impact of PTH on mortality risk in patients with T2DM than in those without. Such association remained significant after adjustment for glycated haemoglobin A1c, diabetes duration, classical cardiovascular risk factors, serum levels of vitamin D, and kidney function (HR, 2.10, 95 percent CI, 1.10–4.10; p=0.030).

These findings suggest that elevated serum levels of PTH, one of the main regulators of calcium homeostasis and vitamin D metabolism, is a significantly strong predictor of all-cause mortality in diabetic patients, according to the investigators.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.