Most Read Articles
Pearl Toh, 27 Mar 2020
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
3 days ago
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Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
Tristan Manalac, 6 days ago
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PTCy-based allogeneic BMT safe, effective for patients with nonmalignant haematological condition

30 Oct 2019
Currently, many opt to stay in the hospital as the insurance only covers inpatient bone marrow transplants, although admittedly that is the costlier choice.

A recent study has shown the safety and effectiveness of post-transplant cyclophosphamide (PTCy)-based nonmyeloablative allogeneic bone marrow transplantation (BMT) in patients with nonmalignant haematologic diseases.

Nine patients treated between 2013 and 2019 were included in this single-centre retrospective series of allogeneic BMT with the use of PTCy in the setting of nonmalignant haematological conditions. Nonmyeloablative conditioning consisted of the following: antihymocyte globulin, fludarabine, low-dose cyclophosphamide and total body irradiation (200 cGy) followed by allogeneic bone marrow infusion.

PTCy, tacrolimus and mycophenolate mofetil were used as prophylaxis for post-BMT graft versus host disease (GVHD).

All nine patients were alive at a median follow-up of 2 years (range, 4–63 months), with donor-derived haematopoiesis and free of significant acute or chronic GVHD. Donors were as follows: haploidentical (n=6), fully matched unrelated (n=2) and fully matched sibling (n=1).

After transplantation, neutrophil and platelet engraftment occurred at a median of 21 and 33 days, respectively. Three patients (33 percent) presented with stage 1–2 acute skin GVHD. Cases of chronic GVHD occurred in three patients (33 percent) with ocular disease (two mild, one moderate).

In addition, none of the patients required systemic immunosuppression beyond months after BMT.

“PTCy-based nonmyeloablative allogeneic BMT is safe and effective for nonmalignant hematologic conditions and should be prospectively compared with historical regimens,” the authors said.

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Most Read Articles
Pearl Toh, 27 Mar 2020
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
3 days ago
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
Tristan Manalac, 6 days ago
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.