Most Read Articles
6 days ago
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
29 Nov 2019
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01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
Stephen Padilla, 13 Feb 2020
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PTCy-based allogeneic BMT safe, effective for patients with nonmalignant haematological condition

30 Oct 2019
Currently, many opt to stay in the hospital as the insurance only covers inpatient bone marrow transplants, although admittedly that is the costlier choice.

A recent study has shown the safety and effectiveness of post-transplant cyclophosphamide (PTCy)-based nonmyeloablative allogeneic bone marrow transplantation (BMT) in patients with nonmalignant haematologic diseases.

Nine patients treated between 2013 and 2019 were included in this single-centre retrospective series of allogeneic BMT with the use of PTCy in the setting of nonmalignant haematological conditions. Nonmyeloablative conditioning consisted of the following: antihymocyte globulin, fludarabine, low-dose cyclophosphamide and total body irradiation (200 cGy) followed by allogeneic bone marrow infusion.

PTCy, tacrolimus and mycophenolate mofetil were used as prophylaxis for post-BMT graft versus host disease (GVHD).

All nine patients were alive at a median follow-up of 2 years (range, 4–63 months), with donor-derived haematopoiesis and free of significant acute or chronic GVHD. Donors were as follows: haploidentical (n=6), fully matched unrelated (n=2) and fully matched sibling (n=1).

After transplantation, neutrophil and platelet engraftment occurred at a median of 21 and 33 days, respectively. Three patients (33 percent) presented with stage 1–2 acute skin GVHD. Cases of chronic GVHD occurred in three patients (33 percent) with ocular disease (two mild, one moderate).

In addition, none of the patients required systemic immunosuppression beyond months after BMT.

“PTCy-based nonmyeloablative allogeneic BMT is safe and effective for nonmalignant hematologic conditions and should be prospectively compared with historical regimens,” the authors said.

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Most Read Articles
6 days ago
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
Stephen Padilla, 13 Feb 2020
A pharmacist intervention appears to be effective in lowering and preventing the incidence of prescribing errors of investigational drugs in oncology clinical trials, a recent study has shown.