Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Psychological stress linked to visceral adiposity

24 Feb 2019

Psychological stress is associated with adiposity as shown by a neurobiological pathway involving the amygdala and bone marrow, suggests a study.

The metabolic activity of the amygdala (AmygA) was associated with baseline body mass index (standardized β, 0.15; p=0.01), visceral adipose tissue (VAT; β, 0.19; p=0.002) and VAT/subcutaneous adipose tissue ratio (β, 0.20; p=0.002). These associations persisted even after adjustments were made for age and sex.

AmygA also correlated with bone marrow activity (β, 0.15; p=0.01), which in turn correlated with VAT (β, 0.34; p<0.001). In addition, pain analysis revealed that increased bone marrow activity mediated the association between AmygA and baseline VAT (p=0.007). Furthermore, after adjusting for age, sex and baseline VAT, an association was found between AmygA and achieved VAT after 1 year (p=0.02).

“Future studies should test whether targeting this mechanism attenuates adiposity and its complications,” the authors said.

This study assessed whether higher AmygA, a neural centre involved in the response to stress, correlated with greater VAT volumes and whether this association was mediated by increased bone marrow activity.

Participants included 246 patients without active oncologic, cardiovascular or inflammatory disease who underwent clinical 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging at the Massachusetts General Hospital in Boston, US. VAT imaging was repeated approximately 1 year later in 68 patients.

The authors used validated methods to measure AmygA, haematopoietic tissue activity and adiposity volumes. The relationship of AmygA with baseline and follow-up VAT was the main outcome measure.

“Epidemiologic data link psychological stress to adiposity, [but] the underlying mechanisms remain uncertain,” the authors noted.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.