Psoriatic arthritis manifestation impairs health-related quality of life
Psoriatic arthritis (PsA) at time of diagnosis worsens health-related quality of life (HRQOL) in comparison to the reference population, a Dutch study has found. Tender joints, enthesitis at clinical examination and back pain as indicators of pain affect HRQOL.
Of 405 patients included in the study, 320 had peripheral arthritis (78 monoarthritis, 151 oligoarthritits and 91 polyarthritis), 39 had dactylitis, 37 had enthesitis and nine had axial disease.
Mean scores of Short Form-36 (SF-36) domains were lower compared to the reference population and similar across subtypes of arthritis. Worse SF-36 scores were associated independently with a higher number of enthesitis locations and tender joints, and with the presence of chronic back pain. Moreover, psoriasis and dactylitis did not correlate with worse score.
This study analysed data collected at time of diagnosis from PsA patients included in the Dutch southwest Early Psoriatic Arthritic (DEPAR) cohort. Eight domains of the Medical Outcomes Study SF-36 questionnaire were used to assess HRQOL.
Patients were grouped according to primary manifestation in arthritis subtypes (ie, mono-, oligo- or polyarthritis) and other subtypes (ie, enthesitis, dactylitis and axial disease). The investigators determined the presence of arthritis, enthesitis, dactylitis, psoriasis and chronic inflammatory back pain in all patients. They determined associations between PsA manifestations and HRQOL using multivariable linear regression.
“PsA is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on HRQOL could be substantial,” the investigators said.