Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Psoriatic arthritis, hyperuricaemia frequently coexist in Asian patients

08 Feb 2018

There appears to be a significant proportion of patients with psoriatic arthritis (PsA) in Hong Kong who have asymptomatic hyperuricaemia, which is closely associated with body mass index (BMI) but not with severity of skin disease, joint involvement or renal function, according to a study.

Researchers looked at 160 PsA patients (mean age 52.6 years; 62.5 percent male; mean BMI, 24.7 kg/m2) from local rheumatology clinics. Assessments included serum uric acid (SUA) level and other clinical parameters. Hyperuricaemia was defined as SUA 360 umol/L in females and 420 umol/L in males.

There were 49 patients identified to have hyperuricaemia (30.6 percent; 65.3 percent male). Mean SUA level was 427.8 umol/L in females and 500.7 umol/L in males. Univariate analysis showed hyperuricaemia to be potentially associated with overweight status, obesity, Psoriasis Area and Severity Index, body surface area, and severe skin involvement.

However, after controlling for potential confounders, only overweight status remained associated with an increased likelihood of hyperuricaemia in PsA, with an odds ratio of 4.4 (95 percent CI, 2.0–9.5). Additionally, BMI showed a moderately positive correlation with SUA level.

Hyperuricaemia had no association with arthritis conditions and duration, lipid profile, and creatinine clearance.

The findings indicate a high rate of asymptomatic hyperuricaemia in Hong Kong Chinese patients with PsA, similar to that in Western countries, researchers noted. High BMI, which represented metabolic dysregulation, might be used as a predictive indicator for hyperuricaemia in this population.

“[B]ody weight monitoring and metabolic problems in PsA patients should not be overlooked in the rheumatologist’s daily practice as they frequently coexist. Further trials targeting the effect of weight reduction in hyperuricaemia in PsA is essential in the foreseeable future,” they said.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.