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Psoriatic arthritis, hyperuricaemia frequently coexist in Asian patients

08 Feb 2018

There appears to be a significant proportion of patients with psoriatic arthritis (PsA) in Hong Kong who have asymptomatic hyperuricaemia, which is closely associated with body mass index (BMI) but not with severity of skin disease, joint involvement or renal function, according to a study.

Researchers looked at 160 PsA patients (mean age 52.6 years; 62.5 percent male; mean BMI, 24.7 kg/m2) from local rheumatology clinics. Assessments included serum uric acid (SUA) level and other clinical parameters. Hyperuricaemia was defined as SUA 360 umol/L in females and 420 umol/L in males.

There were 49 patients identified to have hyperuricaemia (30.6 percent; 65.3 percent male). Mean SUA level was 427.8 umol/L in females and 500.7 umol/L in males. Univariate analysis showed hyperuricaemia to be potentially associated with overweight status, obesity, Psoriasis Area and Severity Index, body surface area, and severe skin involvement.

However, after controlling for potential confounders, only overweight status remained associated with an increased likelihood of hyperuricaemia in PsA, with an odds ratio of 4.4 (95 percent CI, 2.0–9.5). Additionally, BMI showed a moderately positive correlation with SUA level.

Hyperuricaemia had no association with arthritis conditions and duration, lipid profile, and creatinine clearance.

The findings indicate a high rate of asymptomatic hyperuricaemia in Hong Kong Chinese patients with PsA, similar to that in Western countries, researchers noted. High BMI, which represented metabolic dysregulation, might be used as a predictive indicator for hyperuricaemia in this population.

“[B]ody weight monitoring and metabolic problems in PsA patients should not be overlooked in the rheumatologist’s daily practice as they frequently coexist. Further trials targeting the effect of weight reduction in hyperuricaemia in PsA is essential in the foreseeable future,” they said.

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