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21 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
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Psoriasis tied to greater risk of serious infections

24 Jul 2018
Psoriasis raises the risk of serious infections regardless of other traditional risk factors for infections, a recent UK study has shown.

Accessing an electronic medical records database, researchers assessed 187,258 patients with mild psoriasis (mean age 46.4±17.5 years; 48.4 percent male) and 12,442 patients with moderate-to-severe disease (mean age 49.4±15.1 years; 48.7 percent male). Cox proportional hazards regression analyses were performed to evaluate the risk of serious infection according to psoriasis severity.

The incidence rate of psoriasis in patients without psoriasis (n=954,315) was 78.5 per 10,000 person-years, which was lower than that in all psoriasis patients (88.9 per 10,000 person-years). Analysis by disease severity showed that incidence rate was highest in those with moderate-to-severe vs mild psoriasis (145.7 vs 85.7 per 10,000 person-years).

This trend was confirmed through multivariable analysis, which showed that compared with no psoriasis controls, patients with moderate-to-severe psoriasis (adjusted hazard ratio [HR], 1.63; 95 percent CI, 1.52–1.75) are at a greater risk of serious infections than those with mild disease (adjusted HR, 1.18; 1.16–1.21).

The findings were further confirmed in a subsequent analysis of a second cohort that consisted of 83,543 no psoriasis controls, 4,437 mild psoriasis patients and 4,132 moderate-to-severe psoriasis patients.

Incidence of serious infections was likewise greatest in the mild-to-moderate psoriasis group relative to the mild and no psoriasis groups (110.9 vs 97.6 and 75.6 per 10,000 person-years; adjusted HR, 1.27; 1.10–1.47).

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Most Read Articles
21 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.