Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Jairia Dela Cruz, 02 Oct 2018
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
Dr. Joseph Delano Fule Robles, 14 Sep 2018

The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.

07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.

Psoriasis tied to greater risk of serious infections

24 Jul 2018
Psoriasis raises the risk of serious infections regardless of other traditional risk factors for infections, a recent UK study has shown.

Accessing an electronic medical records database, researchers assessed 187,258 patients with mild psoriasis (mean age 46.4±17.5 years; 48.4 percent male) and 12,442 patients with moderate-to-severe disease (mean age 49.4±15.1 years; 48.7 percent male). Cox proportional hazards regression analyses were performed to evaluate the risk of serious infection according to psoriasis severity.

The incidence rate of psoriasis in patients without psoriasis (n=954,315) was 78.5 per 10,000 person-years, which was lower than that in all psoriasis patients (88.9 per 10,000 person-years). Analysis by disease severity showed that incidence rate was highest in those with moderate-to-severe vs mild psoriasis (145.7 vs 85.7 per 10,000 person-years).

This trend was confirmed through multivariable analysis, which showed that compared with no psoriasis controls, patients with moderate-to-severe psoriasis (adjusted hazard ratio [HR], 1.63; 95 percent CI, 1.52–1.75) are at a greater risk of serious infections than those with mild disease (adjusted HR, 1.18; 1.16–1.21).

The findings were further confirmed in a subsequent analysis of a second cohort that consisted of 83,543 no psoriasis controls, 4,437 mild psoriasis patients and 4,132 moderate-to-severe psoriasis patients.

Incidence of serious infections was likewise greatest in the mild-to-moderate psoriasis group relative to the mild and no psoriasis groups (110.9 vs 97.6 and 75.6 per 10,000 person-years; adjusted HR, 1.27; 1.10–1.47).

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Most Read Articles
Pank Jit Sin, 02 May 2018
Leptospirosis is an endemic disease in Malaysia, but may be missed as doctors are not looking for it. 
Jairia Dela Cruz, 02 Oct 2018
Hepatitis D virus infection is highly prevalent in subgroups of individuals with intravenous drug use and those with high-risk sexual behaviour, study has reported. Its prevalence has also increased twofold over time in patients infected with hepatitis B virus.
Dr. Joseph Delano Fule Robles, 14 Sep 2018

The nucleotide analogue tenofovir disoproxil fumarate (TDF) is associated with mild renal impairment in a minority of patients being treated for chronic hepatitis B virus (HBV) infection, a study by the Chinese University of Hong Kong (CUHK) has shown.

07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.